Cellosaurus cell line MM46 [Human mesothelioma] (CVCL

Cellosaurus MM46 [Human mesothelioma] (CVCL_L793)

Cross-references
Cell line name	MM46 [Human mesothelioma]
Synonyms	MM46-P
Accession	CVCL_L793
Resource Identification Initiative	To cite this cell line use: MM46 [Human mesothelioma] (RRID:CVCL_L793)
Comments	Population: Japanese. Doubling time: 11.5 +- 0.5 hours (PubMed=21205078). Transformant: ChEBI; CHEBI_46661; Asbestos. Omics: Genomics; Whole exome sequencing. Omics: Variations; CNV analysis. Omics: Variations; SNP array analysis. Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=21205078). Gene deletion; HGNC; HGNC:7773; NF2; Zygosity=Heterozygous (PubMed=21205078).
Disease	Pleural sarcomatoid mesothelioma (NCIt: C45663) Pleural mesothelioma (ORDO: Orphanet_50251)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	69Y
Category	Cancer cell line
Publications	PubMed=21205078; DOI=10.1111/j.1349-7006.2010.01827.x; PMCID=PMC11158380 Sato A., Torii I., Tao L.-H., Song M., Kondo N., Yoshikawa Y., Hashimoto-Tamaoki T., Hasegawa S., Nakano T., Tsujimura T. Establishment of a cell line from a Japanese patient useful for generating an in vivo model of malignant pleural mesothelioma. Cancer Sci. 102:648-655(2011) PubMed=24916674; DOI=10.1002/ijc.29015 Yoshikawa Y., Sato A., Tsujimura T., Otsuki T., Fukuoka K., Hasegawa S., Nakano T., Hashimoto-Tamaoki T. Biallelic germline and somatic mutations in malignant mesothelioma: multiple mutations in transcription regulators including mSWI/SNF genes. Int. J. Cancer 136:560-571(2015)
Encyclopedic resources	Wikidata; Q54906138
Gene expression databases	GEO; GSM1275978 GEO; GSM1275994
Entry history
Entry creation	06-May-2013
Last entry update	10-Apr-2025
Version number	13