Cellosaurus cell line MM16 (CVCL

Cellosaurus MM16 (CVCL_L789)

Cross-references
Cell line name	MM16
Synonyms	MM16-P
Accession	CVCL_L789
Resource Identification Initiative	To cite this cell line use: MM16 (RRID:CVCL_L789)
Comments	Population: Japanese. Doubling time: 12.4 +- 0.9 hours (PubMed=21205078). Transformant: ChEBI; CHEBI_46661; Asbestos. Omics: Genomics; Whole exome sequencing. Omics: Variations; CNV analysis. Omics: Variations; SNP array analysis. Derived from site: In situ; Lung, pleura; UBERON=UBERON_0000977.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=21205078). Gene deletion; HGNC; HGNC:7773; NF2; Zygosity=Heterozygous (PubMed=21205078).
Disease	Pleural biphasic mesothelioma (NCIt: C45665) Pleural mesothelioma (ORDO: Orphanet_50251)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	65Y
Category	Cancer cell line
Publications	PubMed=21205078; DOI=10.1111/j.1349-7006.2010.01827.x; PMCID=PMC11158380 Ayuko Sato, Ikuko Torii, Li-Hua Tao, Misa Song, Nobuyuki Kondo, Yoshie Yoshikawa, Tomoko Hashimoto-Tamaoki, Seiki Hasegawa, Takashi Nakano, Tohru Tsujimura; Establishment of a cell line from a Japanese patient useful for generating an in vivo model of malignant pleural mesothelioma. Cancer Sci. 102:648-655(2011) PubMed=24916674; DOI=10.1002/ijc.29015 Yoshie Yoshikawa, Ayuko Sato, Tohru Tsujimura, Takemi Otsuki, Kazuya Fukuoka, Seiki Hasegawa, Takashi Nakano, Tomoko Hashimoto-Tamaoki; Biallelic germline and somatic mutations in malignant mesothelioma: multiple mutations in transcription regulators including mSWI/SNF genes. Int. J. Cancer 136:560-571(2015)
Encyclopedic resources	Wikidata; Q54906059
Gene expression databases	GEO; GSM1275963 GEO; GSM1275979
Entry history
Entry creation	06-May-2013
Last entry update	10-Apr-2025
Version number	14