Cellosaurus cell line KE 37.3.2 (CVCL

Cellosaurus KE 37.3.2 (CVCL_L699)

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Cell line name

KE 37.3.2

Synonyms

KE37.3.2; KE37 3.2

Accession

CVCL_L699

Resource Identification Initiative

To cite this cell line use: KE 37.3.2 (RRID:CVCL_L699)

Comments

Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_9555; Tioguanine (6-thioguanine; 6-TG).
Transformant: ChEBI; CHEBI_23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).

Sequence variations

Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Gln2459Ter (c.7375C>T); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:9585; PTCH1; Simple; p.Arg571Gln (c.1712G>A); ClinVar=VCV000819886; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:9884; RB1; Simple; p.Gly310Glu (c.929G>A); ClinVar=VCV000237678; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro153Alafs*28 (c.455dupC) (c.455_456insC) (p.P152fs) (c.459_460insC); ClinVar=VCV000182958; Zygosity=Heterozygous (from parent cell line).

Disease

Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_1327 (KE-37)
Children:

CVCL_L696 (HM 1)	CVCL_3713 (HM 2)	CVCL_L697 (SK 7)
CVCL_L698 (SK 8)

Sex of cell

Male

Age at sampling

27Y