Cellosaurus logo
expasy logo

Cellosaurus Gracie (CVCL_L353)

[Text][XML][JSON]
Cell line name Gracie
Accession CVCL_L353
Resource Identification Initiative To cite this cell line use: Gracie (RRID:CVCL_L353)
Comments Part of: FACC canine tumor cell line panel.
Doubling time: 19.2 hours (PubMed=22916246); 19 hours (PubMed=27257868).
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Bone; UBERON=UBERON_0002481.
Sequence variations
  • Mutation; VGNC; VGNC:46802; SRGAP3; Simple; p.Val850fs (c.2548dupG); Zygosity=Heterozygous (PubMed=31175136).
Disease Canine osteosarcoma (NCIt: C120045)
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Golden Retriever; VBO=VBO_0200610.
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=27197945; PubMed=31175136

Markers:
Dog FHC2010231,235
Dog FHC2054156,172
Dog FHC2079275,279
Dog PEZ1115
Dog PEZ12270,274
Dog PEZ20180
Dog PEZ3124,127
Dog PEZ5111
Dog PEZ6179,183
Dog PEZ8240

Run an STR similarity search on this cell line
Publications

PubMed=21908323; DOI=10.1177/1040638711408064
Liza E. O'Donoghue, Jason P. Rivest, Dawn L. Duval;
Polymerase chain reaction-based species verification and microsatellite analysis for canine cell line validation.
J. Vet. Diagn. Invest. 23:780-785(2011)

PubMed=22916246; DOI=10.1371/journal.pone.0043355; PMCID=PMC3420908
Junko Maeda, Charles R. Yurkon, Hiroshi Fujisawa, Masami Kaneko, Stefan C. Genet, Erica J. Roybal, Garrett Wayne Rota, Ethan R. Saffer, Barbara J. Rose, William H. Hanneman, Douglas H. Thamm, Takamitsu A. Kato;
Genomic instability and telomere fusion of canine osteosarcoma cells.
PLoS ONE 7:e43355.1-e43355.12(2012)

PubMed=27257868; DOI=10.1371/journal.pone.0156689; PMCID=PMC4892608
Junko Maeda, Coral Eva Froning, Colleen A. Brents, Barbara J. Rose, Douglas H. Thamm, Takamitsu A. Kato;
Intrinsic radiosensitivity and cellular characterization of 27 canine cancer cell lines.
PLoS ONE 11:e0156689.1-e0156689.18(2016)

PubMed=27197945; DOI=10.1111/vco.12192; PMCID=PMC5656225
Jared S. Fowles, Deanna D. Dailey, Daniel L. Gustafson, Douglas H. Thamm, Dawn L. Duval;
The Flint Animal Cancer Center (FACC) canine tumour cell line panel: a resource for veterinary drug discovery, comparative oncology and translational medicine.
Vet. Comp. Oncol. 15:481-492(2017)

PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346; PMCID=PMC6679748
Sunetra Das, Rupa Idate, Kathryn E. Cronise, Daniel L. Gustafson, Dawn L. Duval;
Identifying candidate druggable targets in canine cancer cell lines using whole-exome sequencing.
Mol. Cancer Ther. 18:1460-1471(2019)

PubMed=36099278; DOI=10.1371/journal.pone.0274383; PMCID=PMC9469990
Kate Megquier, Jason Turner-Maier, Kathleen Morrill, Xue Li, Jeremy Johnson, Elinor K. Karlsson, Cheryl A. London, Heather L. Gardner;
The genomic landscape of canine osteosarcoma cell lines reveals conserved structural complexity and pathway alterations.
PLoS ONE 17:e0274383.1-e0274383.18(2022)

Cross-references
Encyclopedic resources Wikidata; Q54871668
Gene expression databases GEO; GSM1974789
Entry history
Entry creation06-May-2013
Last entry update10-Apr-2025
Version number20