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Cellosaurus CLBL-1 (CVCL_L322)

[Text version]
Cell line name CLBL-1
Synonyms CLBL1
Accession CVCL_L322
Resource Identification Initiative To cite this cell line use: CLBL-1 (RRID:CVCL_L322)
Comments Part of: FACC canine tumor cell line panel.
Doubling time: 19 hours (PubMed=27257868).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Caution: This cell line is owned by the University of Veterinary Medicine, Vienna who is the sole authorized distributor for both commercial and non-commercial research use.
Derived from site: In situ; Lymph node; UBERON=UBERON_0000027.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Mutation; VGNC; 54284; CCND3; Simple; p.Arg358fs (c.1071_1075delCAGAG); Zygosity=Heterozygous (PubMed=31175136).
  • Mutation; VGNC; 47719; TP53; Simple; p.Ala127Val (c.380C>T); Zygosity=Heterozygous (PubMed=31175136).
  • Mutation; VGNC; 47719; TP53; Simple; p.Arg257His (c.770G>A); Zygosity=Heterozygous (PubMed=31175136).
Disease Canine lymphoma (NCIt: C128121)
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Bernese mountain dog.
Hierarchy Children:
Sex of cell Male
Age at sampling 8Y
Category Cancer cell line
STR profile Source(s): PubMed=27197945; PubMed=31175136

Dog FHC2010231
Dog FHC2054156,164
Dog FHC2079271
Dog PEZ1119
Dog PEZ12274,277
Dog PEZ20176
Dog PEZ3119,124
Dog PEZ5115
Dog PEZ6183,187
Dog PEZ8236,240

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PubMed=20153049; DOI=10.1016/j.leukres.2010.01.021
Rutgen B.C., Hammer S.E., Gerner W., Christian M., de Arespacochaga A.G., Willmann M., Kleiter M., Schwendenwein I., Saalmuller A.
Establishment and characterization of a novel canine B-cell line derived from a spontaneously occurring diffuse large cell lymphoma.
Leuk. Res. 34:932-938(2010)

PubMed=22761949; DOI=10.1371/journal.pone.0040078
Rutgen B.C., Willenbrock S., Reimann-Berg N., Walter I., Fuchs-Baumgartinger A., Wagner S., Kovacic B., Essler S.E., Schwendenwein I., Nolte I., Saalmuller A., Murua Escobar H.
Authentication of primordial characteristics of the CLBL-1 cell line prove the integrity of a canine B-cell lymphoma in a murine in vivo model.
PLoS ONE 7:E40078-E40078(2012)

PubMed=23365669; DOI=10.1371/journal.pone.0054464
Wells J.W., Evans C.H., Scott M.C., Rutgen B.C., O'Brien T.D., Modiano J.F., Cvetkovic G., Tepic S.
Arginase treatment prevents the recovery of canine lymphoma and osteosarcoma cells resistant to the toxic effects of prolonged arginine deprivation.
PLoS ONE 8:E54464-E54464(2013)

PubMed=27257868; DOI=10.1371/journal.pone.0156689
Maeda J., Froning C.E., Brents C.A., Rose B.J., Thamm D.H., Kato T.A.
Intrinsic radiosensitivity and cellular characterization of 27 canine cancer cell lines.
PLoS ONE 11:E0156689-E0156689(2016)

PubMed=27639374; DOI=10.1186/s12917-016-0836-z
Roode S.C., Rotroff D.M., Richards K.L., Moore P.F., Motsinger-Reif A.A., Okamura Y., Mizuno T., Tsujimoto H., Suter S.E., Breen M.
Comprehensive genomic characterization of five canine lymphoid tumor cell lines.
BMC Vet. Res. 12:207.1-207.16(2016)

PubMed=27197945; DOI=10.1111/vco.12192
Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.
The Flint Animal Cancer Center (FACC) canine tumour cell line panel: a resource for veterinary drug discovery, comparative oncology and translational medicine.
Vet. Comp. Oncol. 15:481-492(2017)

PubMed=29674676; DOI=10.1038/s41598-018-23207-7
Taher L., Beck J., Liu W., Roolf C., Soller J.T., Rutgen B.C., Hammer S.E., Chodisetti M., Sender S., Sterenczak K.A., Fuellen G., Junghanss C., Brenig B., Nolte I., Schutz E., Murua Escobar H.
Comparative high-resolution transcriptome sequencing of lymphoma cell lines and de novo lymphomas reveals cell-line-specific pathway dysregulation.
Sci. Rep. 8:6279-6279(2018)

PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346
Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.
Identifying candidate druggable targets in canine cancer cell lines using whole exome sequencing.
Mol. Cancer Ther. 18:1460-1471(2019)

PubMed=32651429; DOI=10.1038/s41598-020-68470-9
Mizuno T., Kato Y., Kaneko M.K., Sakai Y., Shiga T., Kato M., Tsukui T., Takemoto H., Tokimasa A., Baba K., Nemoto Y., Sakai O., Igase M.
Generation of a canine anti-canine CD20 antibody for canine lymphoma treatment.
Sci. Rep. 10:11476-11476(2020)

Chemistry resources ChEMBL-Cells; CHEMBL4295489
ChEMBL-Targets; CHEMBL4296408
PubChem_Cell_line; CVCL_L322
Encyclopedic resources Wikidata; Q54813573
Gene expression databases GEO; GSM1974779
GEO; GSM2143059
GEO; GSM2282267
Entry history
Entry creation06-May-2013
Last entry update29-Jun-2023
Version number21