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Cellosaurus TLBR-1 (CVCL_L177)

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Cell line name TLBR-1
Synonyms TLBR 1; TLBR1; T-cell Lymphoma BReast-1
Accession CVCL_L177
Resource Identification Initiative To cite this cell line use: TLBR-1 (RRID:CVCL_L177)
Comments Doubling time: 55 hours (PubMed=21425149); ~30-40 hours (DSMZ=ACC-904).
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:11364; STAT3; Simple; p.Ser614Arg (c.1842C>G); Zygosity=Unspecified (PubMed=28356514).
Disease Anaplastic large cell lymphoma, ALK-negative (NCIt: C37194)
ALK-negative anaplastic large cell lymphoma (ORDO: Orphanet_300903)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 42Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3027; DSMZ=ACC-904

Markers:
AmelogeninX
CSF1PO10,11
D2S133817,26
D3S135817,18
D5S81811,13 (ATCC=CRL-3027)
11,13,14 (DSMZ=ACC-904)
D7S8208,10
D8S117912,13
D13S31711,14
D16S53912
D18S5113,14
D19S43313,14
D21S1128,29,30
FGA22,24
Penta D10,11
Penta E14,19
TH017,9
TPOX8
vWA16,17

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Publications

PubMed=21425149; DOI=10.1002/cncr.25654; PMCID=PMC4175713
Melissa G. Lechner, Stephen Lade, Daniel J. Liebertz, Henry Miles Prince, Garry Sidney Brody, Howard R. Webster, Alan L. Epstein;
Breast implant-associated, ALK-negative, T-cell, anaplastic, large-cell lymphoma: establishment and characterization of a model cell line (TLBR-1) for this newly emerging clinical entity.
Cancer 117:1478-1489(2011)

PubMed=22791880; DOI=10.1158/1078-0432.CCR-12-0101
Melissa G. Lechner, Carolina Megiel, Connor H. Church, Trevor Edmund Angell, Sarah May Russell, Rikki B. Sevell, Julie K. Jang, Garry Sidney Brody, Alan L. Epstein;
Survival signals and targets for therapy in breast implant-associated ALK -- anaplastic large cell lymphoma.
Clin. Cancer Res. 18:4549-4559(2012)

PubMed=28356514; DOI=10.1073/pnas.1700682114; PMCID=PMC5393253
Jing Chen, Yong Zhang, Michael N. Petrus, Wen-Ming Xiao, Alina Nicolae, Mark Raffeld, Stefania Pittaluga, Richard N. Bamford, Masao Nakagawa, Sunny Tian-Yi Ouyang, Alan L. Epstein ...Show all 16 authors... , Marshall Edward Kadin, Annarose Del Mistro, Richard D. Woessner, Elaine Sarkin Jaffe, Thomas Alexander Waldmann; Show fewer authors
Cytokine receptor signaling is required for the survival of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations.
Proc. Natl. Acad. Sci. U.S.A. 114:3975-3980(2017)

Cross-references
Cell line collections (Providers) ATCC; CRL-3027 - Discontinued
DSMZ; ACC-904
Cell line databases/resources DSMZCellDive; ACC-904
Encyclopedic resources Wikidata; Q54972607
Gene expression databases GEO; GSM2527949
Polymorphism and mutation databases Cosmic; 2814460
Entry history
Entry creation06-May-2013
Last entry update10-Apr-2025
Version number17