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Cellosaurus (CVCL_KY90)

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Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: ENCODE project common cell types; tier 3.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; ChIP-seq; H3K9ac.
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Misspelling: NTERA-S-cl-D1; ArrayExpress=E-MTAB-783; CLO=CLO_0037150; Cosmic=1995598.
Misspelling: NTL-D1; Cosmic=2077191.
Misspelling: NT2101; Cosmic=2163756; PubMed=24812411.
Derived from site: Metastatic; Lung; UBERON=UBERON_0002048.
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.78
Native American0
East Asian, North0.45
East Asian, South1.42
South Asian4.09
European, North53.03
European, South39.23
Disease Embryonal carcinoma (NCIt: C3752)
Embryonal carcinoma (ORDO: Orphanet_180226)
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0034 (NTERA-2)
Sex of cell Male
Age at sampling 22Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-1973; Cosmic-CLP=908454; ECACC=01071221

Markers:
AmelogeninX,Y
CSF1PO10,12
D13S31713
D16S53911,12,13
D18S5114
D19S43314,15.2
D21S1130,31
D2S133822,25
D3S135816
D5S8189,12
D7S82010,12
D8S117913,15
FGA23
Penta D12,13
Penta E5,14
TH019.3
TPOX8
vWA18,19

Run an STR similarity search on this cell line
Web pages Info; ENCODE; -; http://genome.ucsc.edu/ENCODE/protocols/cell/human/NT2-D1_protocol.pdf
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/n/cell-lines-detail-113.html
Info; Wikipedia; -; https://en.wikipedia.org/wiki/NTERA-2
Publications









myeloid leukemia cells.
Kurume Med. J. 42:177-185(1995)


Stephan Beck;
Complete MHC haplotype sequencing for common disease gene mapping.
Genome Res. 14:1176-1187(2004)


Astrid Ulrike Uebing-Czipura, Harry D. Dawson, Gail Scherba;
Immortalization and characterization of lineage-restricted neuronal progenitor cells derived from the porcine olfactory bulb.
J. Neurosci. Methods 170:262-276(2008)



loss via epigenetic DNA methylation confers aggressive phenotypes, negative prognostic impact, and therapeutic relevance.
Clin. Cancer Res. 19:2861-2872(2013)


Yasuhiro Takashima, Ge Guo, Remco Loos, Jennifer Nichols, Gabriella Ficz, Felix Krueger, David Oxley, Fatima Santos, James Clarke, William Mansfield, Wolf Reik ...Show all 13 authors... , Paul Bertone, Austin Gerard Smith; Show fewer authors
Resetting transcription factor control circuitry toward ground-state pluripotency in human.
Cell 158:1254-1269(2014)


Stuart Jay Olshansky, Leonard Hayflick;
The role of the WI-38 cell strain in saving lives and reducing morbidity.
AIMS Public Health 4:127-138(2017)



literature.
Cancer Res. 77:2784-2788(2017)




Cancer Cell 33:386-400.e5(2018)


Fei Sun, Dong-Yi Jiang, Zhi-Min Wang, Qiang Huang;
Quantitative proteomic dataset of whole protein in three melanoma samples of 92.1, 92.1-A and 92.1-B.
Data Brief 45:108592.1-108592.7(2022)

Cross-references
Cell line collections (Providers) ECACC; 01071221
ICLC; HTL97025
IZSLER; BS TCL 204
Cell line databases/resources Cosmic-CLP; 908454
DepMap; ACH-002291
FCS-free; 172-2-320-1-3-3
LINCS_LDP; LCL-1901
Lonza; 1094
Biological sample resources ENCODE; ENCBS374ENC
ENCODE; ENCBS578HFO
ENCODE; ENCBS631LTU
ENCODE; ENCBS810EWQ
Chemistry resources GDSC; 908454
PharmacoDB; NTERASclD1_1169_2019
PubChem_Cell_line; CVCL_3407
Encyclopedic resources Wikidata; Q54931100
Gene expression databases GEO; GSM824855
GEO; GSM824856
GEO; GSM1040297
GEO; GSM1040367
GEO; GSM1670285
Polymorphism and mutation databases Cosmic; 908454
Cosmic; 1995598
Cosmic; 2077191
Cosmic; 2163756
IARC_TP53; 21589
IARC_TP53; 21590
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number43