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Cellosaurus InCELL Hunter U2OS BCL2L1-BIM Protein Binding (CVCL_KW14)

[Text version]
Cell line name InCELL Hunter U2OS BCL2L1-BIM Protein Binding
Synonyms InCELL Hunter U2OS Bcl2L1-Bim
Accession CVCL_KW14
Resource Identification Initiative To cite this cell line use: InCELL Hunter U2OS BCL2L1-BIM Protein Binding (RRID:CVCL_KW14)
Comments Population: Caucasian.
Characteristics: InCELL Hunter cell lines express a transfected target protein fragment tagged with a beta-galactosidase fragment (enhanced ProLabel=ePL). The technology measures compound binding to an intracellular target by detecting changes in protein stability. The amount of fusion is quantified through the addition of substrate and a second enzyme fragment (Enzyme acceptor=EA).
Transfected with: HGNC; 992; BCL2L1.
Transfected with: HGNC; 994; BCL2L11 (with del 1-121 and 182-198).
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; 9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Cell line collections (Providers) DiscoverX; 96-0037C3
Encyclopedic resources Wikidata; Q54897729
Entry history
Entry creation22-Aug-2017
Last entry update05-Oct-2023
Version number8