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Cellosaurus (CVCL_KV50)

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Comments Part of: ICBP43 breast cancer cell line panel.
Part of: JWGray breast cancer cell line panel.
Part of: MD Anderson Cell Lines Project.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK 926.
Population: Caucasian.
Doubling time: 72.94 hours (JWGray panel).
Microsatellite instability: Stable (MSS) (PubMed=12661003; Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:1748; CDH1; Simple; c.1712-1G>A; Zygosity=Homozygous; Note=Splice acceptor mutation (PubMed=19593635).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Asp92His (c.274G>C); Zygosity=Heterozygous (PubMed=19593635; ATCC=HTB-21).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Thr (c.839G>C); ClinVar=VCV000012368; Zygosity=Homozygous (PubMed=16541312; ATCC=HTB-21; Cosmic-CLP=946382; DepMap=ACH-000783).
HLA typing Source: PubMed=25960936
Class I
HLA-AA*02:01,32:01
HLA-BB*15:01,40:02
HLA-CC*02:02,03:03
Class II
HLA-DQDQB1*03:01,03:01
HLA-DRDRB1*11:01,11:01

Source: PubMed=26589293
Class I
HLA-AA*02:01,32:01
HLA-BB*15:01,40:02
HLA-CC*02:02,03:03
Class II
HLA-DQDQA1*05:02,03:02
DQB1*03:04,03:04
HLA-DRDRB1*11:30,13:07
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.37
Native American0
East Asian, North1.38
East Asian, South0
South Asian0
European, North66.52
European, South31.74
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): ATCC=HTB-21; Cosmic-CLP=946382; PubMed=25877200; Technion Genomics Center

Markers:
AmelogeninX
CSF1PO10,12
D10S124814,17
D12S39115
D13S31712
D16S53911
D18S5114,15
D19S43313
D1S165611,15
D21S1132.2
D22S104511,17
D2S133817,21
D2S44111
D3S135818
D5S81812,13
D7S8208,11
D8S117912,13
FGA19,25
Penta D10,11
Penta E12,14
TH018,9.3
TPOX8
vWA15

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Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number49