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Cellosaurus (CVCL_KV49)

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Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: ICBP43 breast cancer cell line panel.
Part of: JWGray breast cancer cell line panel.
Part of: MD Anderson Cell Lines Project.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK 926.
Population: Caucasian.
Doubling time: 72.94 hours (JWGray panel).
Microsatellite instability: Stable (MSS) (PubMed=12661003; Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:1748; CDH1; Simple; c.1712-1G>A; Zygosity=Homozygous; Note=Splice acceptor mutation (PubMed=19593635).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Asp92His (c.274G>C); Zygosity=Heterozygous (PubMed=19593635; ATCC=HTB-21).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Thr (c.839G>C); ClinVar=VCV000012368; Zygosity=Homozygous (PubMed=16541312; ATCC=HTB-21; Cosmic-CLP=946382; DepMap=ACH-000783).
HLA typing Source: PubMed=25960936
Class I
HLA-AA*02:01,32:01
HLA-BB*15:01,40:02
HLA-CC*02:02,03:03
Class II
HLA-DQDQB1*03:01,03:01
HLA-DRDRB1*11:01,11:01

Source: PubMed=26589293
Class I
HLA-AA*02:01,32:01
HLA-BB*15:01,40:02
HLA-CC*02:02,03:03
Class II
HLA-DQDQA1*05:02,03:02
DQB1*03:04,03:04
HLA-DRDRB1*11:30,13:07
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.37
Native American0
East Asian, North1.38
East Asian, South0
South Asian0
European, North66.52
European, South31.74
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): ATCC=HTB-21; Cosmic-CLP=946382; PubMed=25877200; Technion Genomics Center

Markers:
AmelogeninX
CSF1PO10,12
D10S124814,17
D12S39115
D13S31712
D16S53911
D18S5114,15
D19S43313
D1S165611,15
D21S1132.2
D22S104511,17
D2S133817,21
D2S44111
D3S135818
D5S81812,13
D7S8208,11
D8S117912,13
FGA19,25
Penta D10,11
Penta E12,14
TH018,9.3
TPOX8
vWA15

Run an STR similarity search on this cell line
Web pages Info; LINCS; ICBP43; https://lincs.hms.harvard.edu/resources/reagents/icbp43/
Info; MCLP; -; https://tcpaportal.org/mclp/
Info; Synapse; JWGray panel; https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
Provider; MSKCC; -; https://www.mskcc.org/research-advantage/support/technology/tangible-material/human-breast-cell-line-cama-1
Publications




Cancer Cell 33:386-400.e5(2018)

Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number49