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Cellosaurus (CVCL_KV20)

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Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:9855; RAP1A.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Cell type: Epithelial cell; CL=CL_0000066.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61Lys (c.180_181TC>CA) (c.180_181delinsCA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0236 (Calu-6)
Sex of cell Female
Age at sampling 61Y
Category Cancer cell line
Publications


Jia Xie, Hyekyung P. Cho, Nathaniel Twarog, Michele Connelly, Koon-Kiu Yan, Ji-Yang Yu, Shaina N. Porter, Shondra M. Pruett-Miller, Geoffrey Neale, Christopher L. Tinkle, Sara M. Federico ...Show all 13 authors... , Elizabeth A. Stewart, Anang A. Shelat; Show fewer authors
SLFN11 is widely expressed in pediatric sarcoma and induces variable sensitization to replicative stress caused by DNA-damaging agents.
Mol. Cancer Ther. 20:2151-2165(2021)

Entry history
Entry creation02-May-2024
Last entry update14-Aug-2025
Version number4