Cellosaurus cell line (CVCL

Cellosaurus (CVCL_KV13)

Comments

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: KuDOS 95 cell line panel.
Part of: MD Anderson Cell Lines Project.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Population: Caucasian.
Doubling time: 26 hours (Note=In RPMI 1640 + 10% FBS), 32 hours (Note=In ACL-3), 41 hours (Note=In ACL-3 + BSA) (PubMed=3940644); 31.9 hours (PubMed=29681454); ~2 days (CLS=300135); ~72 hours (DSMZ=ACC-734).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Cell type: Epithelial cell; CL=CL_0000066.

Sequence variations

Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61Lys (c.180_181TC>CA) (c.180_181delinsCA); Zygosity=Heterozygous (PubMed=1855224; PubMed=12068308; PubMed=12794755; ATCC=HTB-56; Cosmic-CLP=724859; DepMap=ACH-000264).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Homozygous (PubMed=1855224; PubMed=12794755; ATCC=HTB-56; Cosmic-CLP=724859; DepMap=ACH-000264).

HLA typing

Source: PubMed=26589293

Class I
HLA-A	A*01:01,01:01
HLA-B	B*08:01,35:08
HLA-C	C*07:01,07:01

Genome ancestry

Source: PubMed=30894373

Origin	% genome
African	0.17
Native American	0.95
East Asian, North	0.74
East Asian, South	0
South Asian	0
European, North	66.06
European, South	32.08

Disease

Lung adenocarcinoma (NCIt: C3512)

Species of origin

Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

61Y