Cellosaurus cell line (CVCL

Cellosaurus (CVCL_KV12)

Comments

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: KuDOS 95 cell line panel.
Part of: MD Anderson Cell Lines Project.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Population: Caucasian.
Doubling time: 26 hours (Note=In RPMI 1640 + 10% FBS), 32 hours (Note=In ACL-3), 41 hours (Note=In ACL-3 + BSA) (PubMed=3940644); 31.9 hours (PubMed=29681454); ~2 days (CLS=300135); ~72 hours (DSMZ=ACC-734).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Cell type: Epithelial cell; CL=CL_0000066.

Sequence variations

Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61Lys (c.180_181TC>CA) (c.180_181delinsCA); Zygosity=Heterozygous (PubMed=1855224; PubMed=12068308; PubMed=12794755; ATCC=HTB-56; Cosmic-CLP=724859; DepMap=ACH-000264).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Homozygous (PubMed=1855224; PubMed=12794755; ATCC=HTB-56; Cosmic-CLP=724859; DepMap=ACH-000264).

HLA typing

Source: PubMed=26589293

Class I
HLA-A	A*01:01,01:01
HLA-B	B*08:01,35:08
HLA-C	C*07:01,07:01

Genome ancestry

Source: PubMed=30894373

Origin	% genome
African	0.17
Native American	0.95
East Asian, North	0.74
East Asian, South	0
South Asian	0
European, North	66.06
European, South	32.08

Disease

Lung adenocarcinoma (NCIt: C3512)

Species of origin

Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

61Y

Category

Cancer cell line

STR profile

Source(s): ATCC=HTB-56; CLS=300135; Cosmic-CLP=724859; DSMZ=ACC-734; KCLB=30056; PubMed=20679594; PubMed=25877200

Markers:

Amelogenin	X
CSF1PO	12
D13S317	11
D16S539	13
D18S51	12,16
D19S433	13
D21S11	31
D2S1338	17,26
D3S1358	16
D5S818	11
D7S820	10
D8S1179	10,14
FGA	22
Penta D	13
Penta E	5,14
TH01	9
TPOX	8
vWA	17

Web pages

Info; MCLP; -; https://tcpaportal.org/mclp/
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-473.html
Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/lung-cancer-xenograft/calu-6-xenograft-model/
Provider; MSKCC; -; https://www.mskcc.org/research-advantage/support/technology/tangible-material/calu-06

Publications

molecular basis.
Int. J. Mol. Med. 20:329-335(2007)

switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.
Cancer Cell 18:683-695(2010)

Yasuhiro Takashima, Ge Guo, Remco Loos, Jennifer Nichols, Gabriella Ficz, Felix Krueger, David Oxley, Fatima Santos, James Clarke, William Mansfield, Wolf Reik ...Show all 13 authors... , Paul Bertone, Austin Gerard Smith; Show fewer authors
Resetting transcription factor control circuitry toward ground-state pluripotency in human.
Cell 158:1254-1269(2014)

John J. Fak, Eiko Nishiuchi, Constantin Nicolae Takacs, Maria Teresa Catanese, Ype Peter de Jong, Ira M. Jacobson, Charles Moen Rice, Robert Bernard Darnell;
Hepatitis C virus RNA functionally sequesters miR-122.
Cell 160:1099-1110(2015)

Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson ...Show all 28 authors... , Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

literature.
Cancer Res. 77:2784-2788(2017)

Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita ...Show all 16 authors... , Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar, Jun Takahashi; Show fewer authors
Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model.
Nature 548:592-596(2017)

Cancer Cell 33:386-400.e5(2018)

Entry history

Entry creation

04-Apr-2012

Last entry update

14-Aug-2025

Version number