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Cellosaurus (CVCL_KV11)

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Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: KuDOS 95 cell line panel.
Part of: MD Anderson Cell Lines Project.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Population: Caucasian.
Doubling time: 26 hours (Note=In RPMI 1640 + 10% FBS), 32 hours (Note=In ACL-3), 41 hours (Note=In ACL-3 + BSA) (PubMed=3940644); 31.9 hours (PubMed=29681454); ~2 days (CLS=300135); ~72 hours (DSMZ=ACC-734).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Cell type: Epithelial cell; CL=CL_0000066.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61Lys (c.180_181TC>CA) (c.180_181delinsCA); Zygosity=Heterozygous (PubMed=1855224; PubMed=12068308; PubMed=12794755; ATCC=HTB-56; Cosmic-CLP=724859; DepMap=ACH-000264).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Homozygous (PubMed=1855224; PubMed=12794755; ATCC=HTB-56; Cosmic-CLP=724859; DepMap=ACH-000264).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*01:01,01:01
HLA-BB*08:01,35:08
HLA-CC*07:01,07:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.17
Native American0.95
East Asian, North0.74
East Asian, South0
South Asian0
European, North66.06
European, South32.08
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 61Y
Category Cancer cell line
STR profile Source(s): ATCC=HTB-56; CLS=300135; Cosmic-CLP=724859; DSMZ=ACC-734; KCLB=30056; PubMed=20679594; PubMed=25877200

Markers:
AmelogeninX
CSF1PO12
D13S31711
D16S53913
D18S5112,16
D19S43313
D21S1131
D2S133817,26
D3S135816
D5S81811
D7S82010
D8S117910,14
FGA22
Penta D13
Penta E5,14
TH019
TPOX8
vWA17

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-473.html
Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/lung-cancer-xenograft/calu-6-xenograft-model/
Provider; MSKCC; -; https://www.mskcc.org/research-advantage/support/technology/tangible-material/calu-06
Publications



lines positive and negative for Epstein-Barr virus nuclear antigen. I Physical, cytogenetic, and growth characteristics.
J. Natl. Cancer Inst. 64:465-476(1980)


Lawrence W. Anderson, Howard L. Hosick;
Selection and characterization in culture of mammary tumor cells with distinctive growth properties in vivo.
Cancer Res. 40:1812-1819(1980)




J. Natl. Cancer Inst. 70:649-661(1983)



proteins but retention of response to certain growth factors and hormones by a new malignant human breast cancer cell strain.
Cancer Res. 45:3864-3877(1985)


Isamu Ishiwata, Chieko Ishiwata, Masayuki Soma, Hiroshi Ishikawa;
Establishment of HUOCA-II, a human ovarian clear cell adenocarcinoma cell line, and its angiogenic activity.
J. Natl. Cancer Inst. 78:667-673(1987)



Immortalization of human lymphocytes from a tumor-involved lymph node.
Cancer Res. 47:5181-5188(1987)




Cancer Res. 48:578-583(1988)



Monoclonal antibody PD41 recognizes an antigen restricted to prostate adenocarcinomas.
Cancer Res. 51:1326-1333(1991)



growth factor produced by hepatocellular carcinoma cells: possible involvement of basic fibroblast growth factor in hepatocarcinogenesis.
Jpn. J. Cancer Res. 82:1263-1270(1991)


Jean Bignon, Dominique Emilie;
Intrapleural production of interleukin 6 during mesothelioma and its modulation by gamma-interferon treatment.
Cancer Res. 54:4419-4423(1994)


Robbert J.C. Slebos, Mann H. Lee, Beverly S. Plunkett, Theodore D. Kessis, Bart O. Williams, Tyler Jacks, Lora Hedrick Ellenson, Michael Barry Kastan, Kathleen R. Cho;
p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.
Proc. Natl. Acad. Sci. U.S.A. 91:5320-5324(1994)


Timothy A. Chan, Heiko Hermeking, Christoph Lengauer, Kenneth Wayne Kinzler, Bert Vogelstein;
14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage.
Nature 401:616-620(1999)


Farzaneh Pirnia, Madlaina Breuleux, Erasmus Schneider, Manfred Hochmeister, Susan E. Bates, Andreas Marti, Michel-Andre Hotz, Daniel C. Betticher, Markus M. Borner;
Uncertain identity of doxorubicin-resistant MCF-7 cell lines expressing mutated p53.
J. Natl. Cancer Inst. 92:1535-1536(2000)



pathways for the development of Merkel and skin squamous cell carcinomas.
Int. J. Cancer 99:352-360(2002)



molecular basis.
Int. J. Mol. Med. 20:329-335(2007)




Nat. Biotechnol. 26:1269-1275(2008)




Cancer Immunol. Immunother. 58:1507-1515(2009)


Paula D. Bos, Xiang H.-F. Zhang, Cristina Nadal, Wei-Ping Shu, Roger R. Gomis, Don X. Nguyen, Andy J. Minn, Marc Joan van de Vijver, William Levi Gerald, John A. Foekens, Joan Massague;
Genes that mediate breast cancer metastasis to the brain.
Nature 459:1005-1009(2009)


Louis Guillou, Philippe Terrier, Alain Aurias;
Strong smooth muscle differentiation is dependent on myocardin gene amplification in most human retroperitoneal leiomyosarcomas.
Cancer Res. 69:2269-2278(2009)



switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.
Cancer Cell 18:683-695(2010)


Julie Adam, Ann Hedley, Gabriela Kalna, Ian Philip Mark Tomlinson, Patrick John Pollard, David George Watson, Ralph J. DeBerardinis, Tomer Shlomi, Eytan Ruppin, Eyal Gottlieb;
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
Nature 477:225-228(2011)


Tetsuya Oguri, Hiroaki Ozasa, Takehiro Uemura, Daishi Kasai, Mikinori Miyazaki, Ken Maeno, Shigeki Sato;
Over-expression of MDR1 in amrubicinol-resistant lung cancer cells.
Cancer Chemother. Pharmacol. 68:669-676(2011)


Pedro G. Ferreira, Matthias Barann, Thomas Wieland, Liliana Greger, Maarten van Iterson, Jonas Carlsson Almlof, Paolo Ribeca, Irina Pulyakhina, Daniela Esser, Thomas Giger, Andrew Tikhonov ...Show all 48 authors... , Marc Sultan, Gabrielle Bertier, Daniel Geoffrey MacArthur, Monkol Lek, Esther Lizano, Henk P.J. Buermans, Ismael Padioleau, Thomas Schwarzmayr, Olof Karlberg, Halit Ongen, Helena Kilpinen, Sergi Beltran, Marta Gut, Katja Kahlem, Vyacheslav Amstislavskiy, Oliver Stegle, Matti Pirinen, Stephen B. Montgomery, Peter Donnelly, Mark Ian McCarthy, Paul Flicek, Tim-Matthias Strom, Hans Lehrach, Stefan Schreiber, Ralf Sudbrak, Angel Carracedo, Stylianos E. Antonarakis, Robert Hasler, Ann-Christine Syvanen, Gert-Jan B. van Ommen, Alvis Brazma, Thomas Meitinger, Philip Rosenstiel, Roderic Guigo, Ivo G. Gut, Xavier Estivill, Emmanouil Theophilos Dermitzakis; Show fewer authors
Geuvadis Consortium
Transcriptome and genome sequencing uncovers functional variation in humans.
Nature 501:506-511(2013)


Hangnoh Lee, Charles Joel McManus, Dong-Yeon Cho, Matthew Eaton, Fioranna Renda, Maria Patrizia Somma, Lucy Cherbas, Gemma May, Sara Powell, Da-Yu Zhang, Li-Jun Zhan ...Show all 20 authors... , Alissa Resch, Justen Andrews, Susan E. Celniker, Peter Cherbas, Teresa Maria Przytycka, Maurizio Gatti, Brian Oliver, Brenton R. Graveley, David M. MacAlpine; Show fewer authors
DNA copy number evolution in Drosophila cell lines.
Genome Biol. 15:R70.1-R70.20(2014)


Yasuhiro Takashima, Ge Guo, Remco Loos, Jennifer Nichols, Gabriella Ficz, Felix Krueger, David Oxley, Fatima Santos, James Clarke, William Mansfield, Wolf Reik ...Show all 13 authors... , Paul Bertone, Austin Gerard Smith; Show fewer authors
Resetting transcription factor control circuitry toward ground-state pluripotency in human.
Cell 158:1254-1269(2014)


John J. Fak, Eiko Nishiuchi, Constantin Nicolae Takacs, Maria Teresa Catanese, Ype Peter de Jong, Ira M. Jacobson, Charles Moen Rice, Robert Bernard Darnell;
Hepatitis C virus RNA functionally sequesters miR-122.
Cell 160:1099-1110(2015)


Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson ...Show all 28 authors... , Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)



literature.
Cancer Res. 77:2784-2788(2017)


Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita ...Show all 16 authors... , Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar, Jun Takahashi; Show fewer authors
Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model.
Nature 548:592-596(2017)




Cancer Cell 33:386-400.e5(2018)

Cross-references
Encyclopedic resources Wikidata; Q54808427
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number48