Cellosaurus cell line (CVCL

Cellosaurus (CVCL_KU98)

Comments

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: KuDOS 95 cell line panel.
Part of: MD Anderson Cell Lines Project.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK1980-533.
Population: Caucasian.
Virology: Susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=34339474).
Doubling time: 35 hours (Note=In RPMI 1640 + 10% FBS), 45 hours (Note=In ACL-3), 37 hours (Note=In ACL-3 + BSA) (PubMed=3940644); 40.1 hours (PubMed=29681454); ~84 hours (PubMed=34339474).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Proteomics; Subcellular; Cell surface.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Misspelling: CALV3; Cosmic=1434969.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.

Sequence variations

Mutation; HGNC; HGNC:11998; TP53; Simple; p.Met237Ile (c.711G>T); ClinVar=VCV000634770; Zygosity=Homozygous (PubMed=20557307; ATCC=HTB-55).

HLA typing

Source: PubMed=26589293

Class I
HLA-A	A*24:02,68:01
HLA-B	B*07:02,51:01
HLA-C	C*15:02,15:02

Genome ancestry

Source: PubMed=30894373

Origin	% genome
African	0.63
Native American	0
East Asian, North	2.09
East Asian, South	0
South Asian	0
European, North	67.76
European, South	29.51

Disease

Lung adenocarcinoma (NCIt: C3512)

Species of origin

Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

25Y

Category

Cancer cell line

STR profile

Source(s): AddexBio=C0016001/30; ATCC=HTB-55; CCRID; Cosmic-CLP=687777; KCLB=30055; Millipore=SCC438; PubMed=25877200

Markers:

Amelogenin	X
CSF1PO	11,12
D13S317	12
D16S539	12,14
D18S51	14,17
D19S433	12,13
D21S11	28,30
D2S1338	19
D3S1358	15,18
D5S818	11
D7S820	10,11
D8S1179	11,15
FGA	25
Penta D	9,16
Penta E	5,21
TH01	6,9.3
TPOX	8
vWA	16,17

Web pages

Info; MCLP; -; https://tcpaportal.org/mclp/
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-604.html
Info; Wikipedia; -; https://en.wikipedia.org/wiki/Calu-3
Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/lung-cancer-xenograft/calu-3-xenograft-model/
Provider; MSKCC; -; https://www.mskcc.org/research-advantage/support/technology/tangible-material/calu-3-human-lung-cell-line

Publications

Eur. J. Neurosci. 6:1633-1640(1994)

Nat. Biotechnol. 26:1269-1275(2008)

switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.
Cancer Cell 18:683-695(2010)

Pedro G. Ferreira, Matthias Barann, Thomas Wieland, Liliana Greger, Maarten van Iterson, Jonas Carlsson Almlof, Paolo Ribeca, Irina Pulyakhina, Daniela Esser, Thomas Giger, Andrew Tikhonov ...Show all 48 authors... , Marc Sultan, Gabrielle Bertier, Daniel Geoffrey MacArthur, Monkol Lek, Esther Lizano, Henk P.J. Buermans, Ismael Padioleau, Thomas Schwarzmayr, Olof Karlberg, Halit Ongen, Helena Kilpinen, Sergi Beltran, Marta Gut, Katja Kahlem, Vyacheslav Amstislavskiy, Oliver Stegle, Matti Pirinen, Stephen B. Montgomery, Peter Donnelly, Mark Ian McCarthy, Paul Flicek, Tim-Matthias Strom, Hans Lehrach, Stefan Schreiber, Ralf Sudbrak, Angel Carracedo, Stylianos E. Antonarakis, Robert Hasler, Ann-Christine Syvanen, Gert-Jan B. van Ommen, Alvis Brazma, Thomas Meitinger, Philip Rosenstiel, Roderic Guigo, Ivo G. Gut, Xavier Estivill, Emmanouil Theophilos Dermitzakis; Show fewer authors
Geuvadis Consortium
Transcriptome and genome sequencing uncovers functional variation in humans.
Nature 501:506-511(2013)

Christer Thomsen, Soheila Dolatabadi, Emma Jonasson, Chieh-Yuan Li, David Ruff, Shiaw-Min Chen, Pierre Aman;
Normal and functional TP53 in genetically stable myxoid/round cell liposarcoma.
PLoS ONE 9:e113110.1-e113110.7(2014)

Hangnoh Lee, Charles Joel McManus, Dong-Yeon Cho, Matthew Eaton, Fioranna Renda, Maria Patrizia Somma, Lucy Cherbas, Gemma May, Sara Powell, Da-Yu Zhang, Li-Jun Zhan ...Show all 20 authors... , Alissa Resch, Justen Andrews, Susan E. Celniker, Peter Cherbas, Teresa Maria Przytycka, Maurizio Gatti, Brian Oliver, Brenton R. Graveley, David M. MacAlpine; Show fewer authors
DNA copy number evolution in Drosophila cell lines.
Genome Biol. 15:R70.1-R70.20(2014)

Yasuhiro Takashima, Ge Guo, Remco Loos, Jennifer Nichols, Gabriella Ficz, Felix Krueger, David Oxley, Fatima Santos, James Clarke, William Mansfield, Wolf Reik ...Show all 13 authors... , Paul Bertone, Austin Gerard Smith; Show fewer authors
Resetting transcription factor control circuitry toward ground-state pluripotency in human.
Cell 158:1254-1269(2014)

Leora Witkowski, Jian Carrot-Zhang, Steffen Albrecht, Somayyeh Fahiminiya, Nancy Hamel, Eva Tomiak, David Grynspan, Emmanouil Saloustros, Javad Nadaf, Barbara Rivera, Catherine Gilpin ...Show all 42 authors... , Ester Castellsague, Rachel Silva-Smith, Francois Plourde, Mona Wu, Avi Saskin, Madeleine Arseneault, Rouzan G. Karabakhtsian, Elizabeth A. Reilly, Frederick R. Ueland, Anna Margiolaki, Kitty Pavlakis, Sharon M. Castellino, Janez Lamovec, Helen J. Mackay, Lawrence M. Roth, Thomas M. Ulbright, Tracey A. Bender, Vassilis Georgoulias, Michel Longy, Andrew Berchuck, Marc Tischkowitz, Inga Nagel, Reiner Siebert, Colin J.R. Stewart, Jocelyne Arseneau, Wilson Glenn McCluggage, Blaise A. Clarke, Yasser Riazalhosseini, Martin Hasselblatt, Jacek Majewski, William David Foulkes; Show fewer authors
Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type.
Nat. Genet. 46:438-443(2014)

John J. Fak, Eiko Nishiuchi, Constantin Nicolae Takacs, Maria Teresa Catanese, Ype Peter de Jong, Ira M. Jacobson, Charles Moen Rice, Robert Bernard Darnell;
Hepatitis C virus RNA functionally sequesters miR-122.
Cell 160:1099-1110(2015)

literature.
Cancer Res. 77:2784-2788(2017)

Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita ...Show all 16 authors... , Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar, Jun Takahashi; Show fewer authors
Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model.
Nature 548:592-596(2017)

Cancer Cell 33:386-400.e5(2018)

pathogenic THAP11 functions in gene expression and cell proliferation.
PLoS ONE 15:e0224646.1-e0224646.26(2020)

Entry history

Entry creation

04-Apr-2012

Last entry update

25-Jun-2026

Version number