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Cellosaurus (CVCL_KU83)

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Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: MD Anderson Cell Lines Project.
Part of: NCI RAS program mutant KRAS cell line panel.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK 784.
Population: Caucasian.
Doubling time: 37 hours (PubMed=25984343); 49.8 hours (PubMed=29681454).
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Phenotyping; shRNA library screening.
Omics: Proteomics.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Misspelling: CALV1; Cosmic=1434968.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (MSKCC).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Homozygous (PubMed=12068308; PubMed=12794755; DepMap=ACH-000511).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=31068700).
HLA typing Source: CLS=300141
Class I
HLA-AA*10,11
HLA-BB*15,w35

Source: PubMed=26589293
Class I
HLA-AA*26:01,29:02
HLA-BB*15:01,44:03
HLA-CC*03:04,16:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.74
East Asian, North0.11
East Asian, South0
South Asian9.94
European, North31.4
European, South57.8
Disease Lung squamous cell carcinoma (NCIt: C3493)
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 47Y
Category Cancer cell line
STR profile Source(s): ATCC=HTB-54; CLS=300141; ECACC=93120818; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10
D13S31711,12
D16S53911
D18S5114,17
D19S43313,15
D21S1128
D2S133816,17
D3S135817
D5S81810,12
D7S8209,10
D8S117910
FGA20,21
Penta D9
Penta E11
TH019,9.3 (ATCC=HTB-54; CLS=300141; PubMed=25877200)
9.3 (ECACC=93120818)
TPOX8
vWA15,16

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Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number47