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Cellosaurus (CVCL_KU79)

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Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: MD Anderson Cell Lines Project.
Part of: NCI RAS program mutant KRAS cell line panel.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK 784.
Population: Caucasian.
Doubling time: 37 hours (PubMed=25984343); 49.8 hours (PubMed=29681454).
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Phenotyping; shRNA library screening.
Omics: Proteomics.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Misspelling: CALV1; Cosmic=1434968.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (MSKCC).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Homozygous (PubMed=12068308; PubMed=12794755; DepMap=ACH-000511).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=31068700).
HLA typing Source: CLS=300141
Class I
HLA-AA*10,11
HLA-BB*15,w35

Source: PubMed=26589293
Class I
HLA-AA*26:01,29:02
HLA-BB*15:01,44:03
HLA-CC*03:04,16:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.74
East Asian, North0.11
East Asian, South0
South Asian9.94
European, North31.4
European, South57.8
Disease Lung squamous cell carcinoma (NCIt: C3493)
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 47Y
Category Cancer cell line
STR profile Source(s): ATCC=HTB-54; CLS=300141; ECACC=93120818; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10
D13S31711,12
D16S53911
D18S5114,17
D19S43313,15
D21S1128
D2S133816,17
D3S135817
D5S81810,12
D7S8209,10
D8S117910
FGA20,21
Penta D9
Penta E11
TH019,9.3 (ATCC=HTB-54; CLS=300141; PubMed=25877200)
9.3 (ECACC=93120818)
TPOX8
vWA15,16

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Provider; MSKCC; -; https://www.mskcc.org/research-advantage/support/technology/tangible-material/calu-1-human-lung-cell-line
Publications




J. Natl. Cancer Inst. 53:751-757(1974)



lung and placenta.
J. Natl. Cancer Inst. 56:911-917(1976)



lines positive and negative for Epstein-Barr virus nuclear antigen. I Physical, cytogenetic, and growth characteristics.
J. Natl. Cancer Inst. 64:465-476(1980)


Philip A. Pizzo, James Gadek, Elaine Sarkin Jaffe, Maria Santaella, Carl Hammer, Michael M. Frank, Gregory Reaman, Ligita Novikovs;
Characterization of lymphoma-derived cell lines: comparison of cell lines positive and negative for Epstein-Barr virus nuclear antigen II. Surface markers.
J. Natl. Cancer Inst. 64:477-483(1980)


Lawrence W. Anderson, Howard L. Hosick;
Selection and characterization in culture of mammary tumor cells with distinctive growth properties in vivo.
Cancer Res. 40:1812-1819(1980)


David H. Weinberg, Gary Ketner;
A cell line that supports the growth of a defective early region 4 deletion mutant of human adenovirus type 2.
Proc. Natl. Acad. Sci. U.S.A. 80:5383-5386(1983)



growth factor produced by hepatocellular carcinoma cells: possible involvement of basic fibroblast growth factor in hepatocarcinogenesis.
Jpn. J. Cancer Res. 82:1263-1270(1991)


Daniele Bani, Geri Toccafondi, Fabio Almerigogna, Omero Fini Storchi;
Characterization of a novel cell line from pleomorphic adenoma of the parotid gland with myoepithelial phenotype and producing interleukin-6 as an autocrine growth factor.
Cancer 70:559-568(1992)


Robbert J.C. Slebos, Mann H. Lee, Beverly S. Plunkett, Theodore D. Kessis, Bart O. Williams, Tyler Jacks, Lora Hedrick Ellenson, Michael Barry Kastan, Kathleen R. Cho;
p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.
Proc. Natl. Acad. Sci. U.S.A. 91:5320-5324(1994)


Dennis E. Hallahan, Donald William Kufe;
Cellular and molecular mechanisms of radioresistance.
(In book chapter) Head and neck cancer. Cancer treatment and research, Vol. 74; Hong, Waun Ki & Weber, Randal S. (eds.); pp.131-140; Springer; Boston; USA (1995)



endometriotic cells containing episomal simian virus 40 DNA.
Am. J. Pathol. 154:1245-1257(1999)


Timothy A. Chan, Heiko Hermeking, Christoph Lengauer, Kenneth Wayne Kinzler, Bert Vogelstein;
14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage.
Nature 401:616-620(1999)



pathways for the development of Merkel and skin squamous cell carcinomas.
Int. J. Cancer 99:352-360(2002)




Nat. Biotechnol. 26:1269-1275(2008)




Cancer Immunol. Immunother. 58:1507-1515(2009)


Paula D. Bos, Xiang H.-F. Zhang, Cristina Nadal, Wei-Ping Shu, Roger R. Gomis, Don X. Nguyen, Andy J. Minn, Marc Joan van de Vijver, William Levi Gerald, John A. Foekens, Joan Massague;
Genes that mediate breast cancer metastasis to the brain.
Nature 459:1005-1009(2009)


Louis Guillou, Philippe Terrier, Alain Aurias;
Strong smooth muscle differentiation is dependent on myocardin gene amplification in most human retroperitoneal leiomyosarcomas.
Cancer Res. 69:2269-2278(2009)


Junko Matsuoka, Yuhiko Fuyuhiro, Osamu Shinto, Tetsuji Sawada, Masaichi Ohira, Kosei Hirakawa;
Establishment and characterization of a new hypoxia-resistant cancer cell line, OCUM-12/Hypo, derived from a scirrhous gastric carcinoma.
Br. J. Cancer 102:898-907(2010)



switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.
Cancer Cell 18:683-695(2010)


Julie Adam, Ann Hedley, Gabriela Kalna, Ian Philip Mark Tomlinson, Patrick John Pollard, David George Watson, Ralph J. DeBerardinis, Tomer Shlomi, Eytan Ruppin, Eyal Gottlieb;
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
Nature 477:225-228(2011)


Tetsuya Oguri, Hiroaki Ozasa, Takehiro Uemura, Daishi Kasai, Mikinori Miyazaki, Ken Maeno, Shigeki Sato;
Over-expression of MDR1 in amrubicinol-resistant lung cancer cells.
Cancer Chemother. Pharmacol. 68:669-676(2011)


Pedro G. Ferreira, Matthias Barann, Thomas Wieland, Liliana Greger, Maarten van Iterson, Jonas Carlsson Almlof, Paolo Ribeca, Irina Pulyakhina, Daniela Esser, Thomas Giger, Andrew Tikhonov ...Show all 48 authors... , Marc Sultan, Gabrielle Bertier, Daniel Geoffrey MacArthur, Monkol Lek, Esther Lizano, Henk P.J. Buermans, Ismael Padioleau, Thomas Schwarzmayr, Olof Karlberg, Halit Ongen, Helena Kilpinen, Sergi Beltran, Marta Gut, Katja Kahlem, Vyacheslav Amstislavskiy, Oliver Stegle, Matti Pirinen, Stephen B. Montgomery, Peter Donnelly, Mark Ian McCarthy, Paul Flicek, Tim-Matthias Strom, Hans Lehrach, Stefan Schreiber, Ralf Sudbrak, Angel Carracedo, Stylianos E. Antonarakis, Robert Hasler, Ann-Christine Syvanen, Gert-Jan B. van Ommen, Alvis Brazma, Thomas Meitinger, Philip Rosenstiel, Roderic Guigo, Ivo G. Gut, Xavier Estivill, Emmanouil Theophilos Dermitzakis; Show fewer authors
Geuvadis Consortium
Transcriptome and genome sequencing uncovers functional variation in humans.
Nature 501:506-511(2013)


Hangnoh Lee, Charles Joel McManus, Dong-Yeon Cho, Matthew Eaton, Fioranna Renda, Maria Patrizia Somma, Lucy Cherbas, Gemma May, Sara Powell, Da-Yu Zhang, Li-Jun Zhan ...Show all 20 authors... , Alissa Resch, Justen Andrews, Susan E. Celniker, Peter Cherbas, Teresa Maria Przytycka, Maurizio Gatti, Brian Oliver, Brenton R. Graveley, David M. MacAlpine; Show fewer authors
DNA copy number evolution in Drosophila cell lines.
Genome Biol. 15:R70.1-R70.20(2014)


John J. Fak, Eiko Nishiuchi, Constantin Nicolae Takacs, Maria Teresa Catanese, Ype Peter de Jong, Ira M. Jacobson, Charles Moen Rice, Robert Bernard Darnell;
Hepatitis C virus RNA functionally sequesters miR-122.
Cell 160:1099-1110(2015)


Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson ...Show all 28 authors... , Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)



literature.
Cancer Res. 77:2784-2788(2017)


Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita ...Show all 16 authors... , Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar, Jun Takahashi; Show fewer authors
Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model.
Nature 548:592-596(2017)


Mario Oscar Salazar, Lydia Ines Puricelli, Maria Eugenia Monge;
Metabolic footprinting of a clear cell renal cell carcinoma in vitro model for human kidney cancer detection.
J. Proteome Res. 17:3877-3888(2018)


Katsushi Tokunaga, Masao Nagasaki, Seiji Kito, Keiichi Isoyama, Masafumi Onodera, Hideo Kaneko, Naomichi Matsumoto, Fumihiko Matsuda, Keitaro Matsuo, Yoshiyuki Takahashi, Tomoji Mashimo ...Show all 13 authors... , Seiji Kojima, Tomoo Ogi; Show fewer authors
Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome.
Sci. Adv. 6:eabd7197.1-eabd7197.15(2020)

Cross-references
Cell line collections (Providers) CancerTools; 161905
CLS; 300141
ECACC; 93120818
ICLC; HTL95002
IZSLER; BS TCL 76
Cell line databases/resources cancercelllines; CVCL_0608
CCRID; 3101HUMTCHu192
Cell_Model_Passport; SIDM01545
DepMap; ACH-000511
IGRhCellID; Calu1
LINCS_HMS; 50009
LINCS_LDP; LCL-1580
Biological sample resources BioSample; SAMN10988371
Chemistry resources ChEMBL-Cells; CHEMBL3308031
ChEMBL-Targets; CHEMBL613505
GDSC; 724858
PharmacoDB; Calu1_178_2019
PubChem_Cell_line; CVCL_0608
Encyclopedic resources Wikidata; Q54808423
Gene expression databases GEO; GSM108801
GEO; GSM108802
GEO; GSM206451
GEO; GSM253387
GEO; GSM274735
GEO; GSM274736
GEO; GSM434324
GEO; GSM784250
GEO; GSM794261
GEO; GSM817063
GEO; GSM843486
GEO; GSM886914
GEO; GSM887980
GEO; GSM1374430
GEO; GSM1374431
GEO; GSM1374432
Polymorphism and mutation databases Cosmic; 724858
Cosmic; 755615
Cosmic; 929968
Cosmic; 933574
Cosmic; 934465
Cosmic; 934541
Cosmic; 1089224
Cosmic; 1146872
Cosmic; 1188586
Cosmic; 1434968
Cosmic; 2060525
Cosmic; 2125218
Cosmic; 2645023
Cosmic; 2646653
Cosmic; 2668264
Cosmic; 2772160
IARC_TP53; 8200
IARC_TP53; 21263
LiGeA; CCLE_612
Progenetix; CVCL_0608
Proteomic databases PRIDE; PXD002556
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number47