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Cellosaurus SU-DHL-4/12V (CVCL_KU32)

[Text version]
Cell line name SU-DHL-4/12V
Synonyms DHL-4/12V
Accession CVCL_KU32
Resource Identification Initiative To cite this cell line use: SU-DHL-4/12V (RRID:CVCL_KU32)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:28445; Vincristine (VCR).
Derived from site: In situ; Peritoneal effusion; UBERON=UBERON_0001268.
Sequence variations
  • Gene fusion; HGNC; 990; BCL2 + HGNC; 5477; IGH; Name(s)=IGH-BCL2 (from parent cell line).
  • Mutation; HGNC; 3527; EZH2; Simple; p.Tyr646Ser (c.1937A>C) (Y641S); ClinVar=VCV000376218; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 3527; EZH2; Simple; p.Tyr666Asn (c.1996T>A) (Y661N); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Homozygous (from parent cell line).
Disease Diffuse large B-cell lymphoma germinal center B-cell type (NCIt: C36080)
Diffuse large B-cell lymphoma (ORDO: Orphanet_544)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0539 (SU-DHL-4)
Sex of cell Male
Age at sampling 38Y
Category Cancer cell line
Publications

PubMed=18357372; DOI=10.3892/or.19.4.889
Pop I., Pop L., Vitetta E.S., Ghetie M.-A.
Generation of multidrug resistant lymphoma cell lines stably expressing P-glycoprotein.
Oncol. Rep. 19:889-895(2008)

Cross-references
Cell line databases/resources cancercelllines; CVCL_KU32
Encyclopedic resources Wikidata; Q54970719
Entry history
Entry creation22-Aug-2017
Last entry update05-Oct-2023
Version number15