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Cellosaurus 2B8 [Mouse hybridoma against human MS4A1] (CVCL_KR60)

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Cell line name 2B8 [Mouse hybridoma against human MS4A1]
Synonyms IDEC-2B8
Accession CVCL_KR60
Resource Identification Initiative To cite this cell line use: 2B8 [Mouse hybridoma against human MS4A1] (RRID:CVCL_KR60)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); HB-11388.
Biotechnology: The monoclonal antibody produced by this hybridoma was used to prepare the humanized rituximab (IDEC-C2B8) therapeutic antibody.
Monoclonal antibody isotype: IgG1, kappa.
Monoclonal antibody target: UniProtKB; P11836; Human MS4A1/CD20.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy Parent: CVCL_6450 (Sp2/01-Ag)
Category Hybridoma
Publications

PubMed=7506951; DOI=10.1182/blood.V83.2.435.435
Mitchell E. Reff, Kristin Carner, Karen S. Chambers, Paul C. Chinn, John E. Leonard, Ron Raab, Roland A. Newman, Nabil Hanna, Darrell R. Anderson;
Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20.
Blood 83:435-445(1994)

Patent=US5736137
Darrell R. Anderson, Nabil Hanna, John E. Leonard, Roland A. Newman, Mitchell E. Reff, William Harry Rastetter;
Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma.
Patent number US5736137, 07-Apr-1998

Cross-references
Encyclopedic resources Wikidata; Q54584310
Entry history
Entry creation22-Aug-2017
Last entry update21-Mar-2023
Version number6