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Cellosaurus AR300 (CVCL_JY57)

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Cell line name AR300
Accession CVCL_JY57
Resource Identification Initiative To cite this cell line use: AR300 (RRID:CVCL_JY57)
Comments Selected for resistance to: ChEBI; CHEBI_138016; 5-(N-methyl-N-propyl)amiloride (MPA).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Cell type: Fibroblast of lung; CL=CL_0002553.
Sequence variations
  • Mutation; UniProtKB; P48761; Slc9a1; Simple; p.Leu167Phe (c.499C>T); Zygosity=Homozygous (PubMed=8389452).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_JY56 (AR40)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=3021747; DOI=10.1016/S0021-9258(18)66915-7
Arlette Franchi, Edward Jethro Cragoe Jr., Jacques Pouyssegur;
Isolation and properties of fibroblast mutants overexpressing an altered Na+/H+ antiporter.
J. Biol. Chem. 261:14614-14620(1986)

PubMed=8389452; DOI=10.1073/pnas.90.10.4508; PMCID=PMC46541
Laurent Counillon, Arlette Franchi, Jacques Pouyssegur;
A point mutation of the Na+/H+ exchanger gene (NHE1) and amplification of the mutated allele confer amiloride resistance upon chronic acidosis.
Proc. Natl. Acad. Sci. U.S.A. 90:4508-4512(1993)

Cross-references
Encyclopedic resources Wikidata; Q54750359
Entry history
Entry creation22-Aug-2017
Last entry update19-Dec-2024
Version number9