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Cellosaurus MCF-10A TP53(-/-) (CVCL_JM25)

[Text version]
Cell line name MCF-10A TP53(-/-)
Synonyms TP53 (-/-) MCF10A
Accession CVCL_JM25
Resource Identification Initiative To cite this cell line use: MCF-10A TP53(-/-) (RRID:CVCL_JM25)
Comments Knockout cell: Method=Homologous recombination; HGNC; HGNC:11998; TP53.
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0598 (MCF-10A)
Sex of cell Female
Age at sampling 36Y
Category Spontaneously immortalized cell line
Publications

PubMed=20562907; DOI=10.1038/onc.2010.220; PMCID=PMC3164558
Michele B. Weiss, Michele I. Vitolo, Morassa Mohseni, David M. Rosen, Samuel Ray Denmeade, Ben Ho Park, David Joseph Weber, Kurtis E. Bachman;
Deletion of p53 in human mammary epithelial cells causes chromosomal instability and altered therapeutic response.
Oncogene 29:4715-4724(2010)

Cross-references
Cell line collections (Providers) Horizon_Discovery; HD+101-005
Encyclopedic resources Wikidata; Q54904293
Entry history
Entry creation15-May-2017
Last entry update19-Dec-2024
Version number12