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Cellosaurus VU-SCC-040 (CVCL_JL62)

[Text version]
Cell line name VU-SCC-040
Synonyms VU-SCC-40; 92VU040; 92VU040T
Accession CVCL_JL62
Resource Identification Initiative To cite this cell line use: VU-SCC-040 (RRID:CVCL_JL62)
Comments Doubling time: 27 +- 3 hours (PubMed=9139877).
Omics: Genomics; Whole genome sequencing; Low read coverage.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=31541927).
  • Mutation; HGNC; HGNC:20250; AJUBA; Simple; p.Ser263fs (c.788_789delCT); Zygosity=Homozygous (PubMed=31541927).
  • Mutation; HGNC; HGNC:1509; CASP8; Simple; p.Glu17Lys (c.49G>A); Zygosity=Heterozygous (PubMed=31541927).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Asn390Lys (c.1170C>A); Zygosity=Homozygous (PubMed=31541927).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Leu989Val (c.2965C>G); Zygosity=Heterozygous (PubMed=31541927).
  • Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=15735012; PubMed=23613873).
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 65Y
Category Cancer cell line
Publications

PubMed=8824719; DOI=10.1002/(SICI)1098-2264(199601)15:1<1::AID-GCC1>3.0.CO;2-8
Mario A.J.A. Hermsen, Hans Joenje, Fre Arwert, Marij J.P. Welters, Boudewijn J.M. Braakhuis, Marian Bagnay, Andries Westerveld, Rosalyn M. Slater;
Centromeric breakage as a major cause of cytogenetic abnormalities in oral squamous cell carcinoma.
Genes Chromosomes Cancer 15:1-9(1996)

PubMed=9139877; DOI=10.1002/(SICI)1097-0215(19970502)71:3<410::AID-IJC18>3.0.CO;2-J
Marij J.P. Welters, Anne Marie Josephine Fichtinger-Schepman, Robert A. Baan, Mario A.J.A. Hermsen, Wim J.F. van der Vijgh, Jacqueline Cloos, Boudewijn J.M. Braakhuis;
Relationship between the parameters cellular differentiation, doubling time and platinum accumulation and cisplatin sensitivity in a panel of head and neck cancer cell lines.
Int. J. Cancer 71:410-415(1997)

PubMed=15735012; DOI=10.1158/0008-5472.CAN-04-3665
Hester J.T. van Zeeburg, Peter J.F. Snijders, Gerard Pals, Mario A.J.A. Hermsen, Martin A. Rooimans, Grover Bagby, Jean Soulier, Eliane Gluckman, Johan Wennerberg, C. Rene Leemans, Hans Joenje, Ruud H. Brakenhoff;
Generation and molecular characterization of head and neck squamous cell lines of Fanconi anemia patients.
Cancer Res. 65:1271-1276(2005)

PubMed=23613873; DOI=10.1371/journal.pone.0061555; PMCID=PMC3629194
Sanne R. Martens-de Kemp, Simone U. Dalm, Fiona M.J. Wijnolts, Arjen Brink, Richard J. Honeywell, Godefridus Johannes Peters, Boudewijn J.M. Braakhuis, Ruud H. Brakenhoff;
DNA-bound platinum is the major determinant of cisplatin sensitivity in head and neck squamous carcinoma cells.
PLoS ONE 8:e61555.1-e61555.9(2013)

PubMed=26122845; DOI=10.1158/0008-5472.CAN-15-0528
Chantal Stoepker, Najim Ameziane, Petra van der Lelij, Irsan E. Kooi, Anneke B. Oostra, Martin A. Rooimans, Saskia E. van Mil, Arjen Brink, Ralf Dietrich, Jesper A. Balk, Bauke Ylstra ...Show all 14 authors... , Hans Joenje, Stephan M. Feller, Ruud H. Brakenhoff; Show fewer authors
Defects in the Fanconi anemia pathway and chromatid cohesion in head and neck cancer.
Cancer Res. 75:3543-3553(2015)

PubMed=31541927; DOI=10.1016/j.oraloncology.2019.09.004; PMCID=PMC7372097
Anne M. van Harten, Jos B. Poell, Marijke Buijze, Arjen Brink, Susanne I. Wells, C. Rene Leemans, Rob M.F. Wolthuis, Ruud H. Brakenhoff;
Characterization of a head and neck cancer-derived cell line panel confirms the distinct TP53-proficient copy number-silent subclass.
Oral Oncol. 98:53-61(2019)

Cross-references
Encyclopedic resources Wikidata; Q54993380
Polymorphism and mutation databases IARC_TP53; 21673
Entry history
Entry creation15-May-2017
Last entry update10-Apr-2025
Version number10