Cellosaurus cell line AT-2 (CVCL

Cellosaurus AT-2 (CVCL_JK53)

Cross-references
Cell line name	AT-2
Accession	CVCL_JK53
Resource Identification Initiative	To cite this cell line use: AT-2 (RRID:CVCL_JK53)
Comments	Characteristics: From transgenic mice expressing a fusion gene comprised of the rat alpha-cardiac myosin heavy chain promoter and the SV40 early region (MHC-TAG). Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen. Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40). Derived from site: In situ; Heart; UBERON=UBERON_0000948. Cell type: Cardiomyocyte; CL=CL_0002495.
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090) Breed/subspecies: C3HeB/FeJ transgenic.
Age at sampling	Age unspecified
Category	Transformed cell line
Publications	PubMed=1377879; DOI=10.1152/ajpheart.1992.262.6.H1867 Ellen B. Katz, Mark E. Steinhelper, Joseph B. Delcarpio, Adil I. Daud, William Creighton Claycomb, Loren J. Field; Cardiomyocyte proliferation in mice expressing alpha-cardiac myosin heavy chain-SV40 T-antigen transgenes. Am. J. Physiol. 262:H1867-H1876(1992) PubMed=8498581; DOI=10.1152/ajpheart.1993.264.5.H1693 Adil I. Daud, Nicholas A. Lanson Jr., William Creighton Claycomb, Loren J. Field; Identification of SV40 large T-antigen-associated proteins in cardiomyocytes from transgenic mice. Am. J. Physiol. 264:H1693-H1700(1993) PubMed=10908350; DOI=10.1093/nar/28.15.2882; PMCID=PMC102680 Nicholas A. Lanson Jr., Daniel B. Egeland, Brenda A. Royals, William Creighton Claycomb; The MRE11-NBS1-RAD50 pathway is perturbed in SV40 large T antigen-immortalized AT-1, AT-2 and HL-1 cardiomyocytes. Nucleic Acids Res. 28:2882-2892(2000)
Encyclopedic resources	Wikidata; Q54750828
Entry history
Entry creation	15-May-2017
Last entry update	14-Aug-2025
Version number	11