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Cellosaurus Hep-2013 (CVCL_JG88)

[Text version]
Cell line name Hep-2013
Synonyms Hep2013
Accession CVCL_JG88
Resource Identification Initiative To cite this cell line use: Hep-2013 (RRID:CVCL_JG88)
Comments Characteristics: The CCDN1, CDK4 and TERT genes expression can be silenced by administration of tetracycline/doxycycline through a Tet-Off system (PubMed=33060611).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1582; CCND1.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1773; CDK4 (Note=With p.Arg24Cys).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
Genetic integration: Method=Transduction; Gene=UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (Note=With p.Met1_Arg360del).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Cell type: Hepatocyte; CL=CL_0000182.
Disease Biliary atresia (NCIt: C34421)
Isolated biliary atresia (ORDO: Orphanet_30391)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 3Y10M
Category Telomerase immortalized cell line
STR profile Source(s): JCRB=JCRB1696

Markers:
AmelogeninX
CSF1PO9,12
D5S81811,12
D7S8209,11
D13S31710,11
D16S5399
TH017,9
TPOX8,11
vWA14

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Publications

PubMed=33060611; DOI=10.1038/s41598-020-73992-3; PMCID=PMC7567112
Nishiwaki M., Toyoda M., Oishi Y., Ishida S., Horiuchi S.-i., Makino-Itou H., Kimura T., Ohno S.-i., Ohkura T., Enosawa S., Akutsu H., Nakazawa A., Kasahara M., Kiyono T., Umezawa A.
Immortalization of human hepatocytes from biliary atresia with CDK4(R24C), cyclin D1, and TERT for cytochrome P450 induction testing.
Sci. Rep. 10:17503.1-17503.13(2020)

Cross-references
Cell line collections (Providers) JCRB; JCRB1696
Encyclopedic resources Wikidata; Q54882757
Entry history
Entry creation15-May-2017
Last entry update19-Dec-2024
Version number13