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Cellosaurus H/Rb-M (CVCL_JE92)

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Cell line name H/Rb-M
Synonyms H/RB-M; H/Rb-M-CL5
Accession CVCL_JE92
Resource Identification Initiative To cite this cell line use: H/Rb-M (RRID:CVCL_JE92)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-10707.
Characteristics: Corrects the lack of expression of RB1 in the parent cell line which is due to an homozygous mutation p.Tyr325Ter (c.975T>A).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:9884; RB1.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Mutation; HGNC; HGNC:6871; MAPK1; Simple; p.Arg79Lys (c.236G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Thr (c.839G>C); ClinVar=VCV000012368; Zygosity=Homozygous (from parent cell line).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0126 (5637)
Sex of cell Male
Age at sampling 68Y
Category Cancer cell line
Publications

Patent=WO1992022640A1
Rei Takahashi, William F. Benedict;
Rb transferred cells and method.
Patent number WO1992022640A1, 23-Dec-1992

Cross-references
Cell line databases/resources cancercelllines; CVCL_JE92
CCRID; 4201PAT-CCTCC00099
Encyclopedic resources Wikidata; Q54871902
Entry history
Entry creation15-May-2017
Last entry update19-Dec-2024
Version number16