Cellosaurus cell line FU-266 clone E1 (CVCL

Cellosaurus FU-266 clone E1 (CVCL_J236)

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Cell line name

FU-266 clone E1

Synonyms

FU-266 (E1)

Accession

CVCL_J236

Resource Identification Initiative

To cite this cell line use: FU-266 clone E1 (RRID:CVCL_J236)

Comments

Population: Caucasian.
Characteristics: Produces IgE lambda (from parent cell line).
Selected for resistance to: ChEBI; CHEBI_9555; Tioguanine (6-thioguanine; 6-TG).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Plasma cell; CL=CL_0000786.

Sequence variations

Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Lys601Asn (c.1803A>T); ClinVar=VCV000376285; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Gly141Asp (c.422G>A); ClinVar=VCV001491786; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ala161Thr (c.481G>A); ClinVar=VCV000161518; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; HGNC:12033; TRAF3; Simple; p.Lys550Leufs*3 (c.1648_1649insT); Zygosity=Homozygous (from parent cell line).

Disease

Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_J235 (FU-266)
Children:

CVCL_9087 (36)

CVCL_9088 (SHM-A6)

CVCL_3419 (SHM-D33)

Sex of cell

Male

Age at sampling

53Y