Cellosaurus cell line P388/ADR (CVCL

Cellosaurus P388/ADR (CVCL_IZ75)

Cross-references
Cell line name	P388/ADR
Synonyms	P388/Adr; P388/adr
Accession	CVCL_IZ75
Resource Identification Initiative	To cite this cell line use: P388/ADR (RRID:CVCL_IZ75)
Comments	Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin). Transformant: ChEBI; CHEBI_34342; 3-methylcholanthrene (3-MC; 20-methylcholanthrene; 20-MC; MCA).
Disease	Mouse lymphoma (NCIt: C21602)
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090) Breed/subspecies: DBA/2.
Hierarchy	Parent: CVCL_7222 (P388)
Sex of cell	Female
Age at sampling	Age unspecified
Category	Cancer cell line
Web pages	Info; NCI DTP; NCI-60 additional lines; https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm
Publications	PubMed=3335022 Michael Curtis Alley, Dominic A. Scudiero, Anne Monks, Miriam L. Hursey, Maciej J. Czerwinski, Donald L. Fine, Betty Jane Abbott, Joseph G. Mayo, Robert H. Shoemaker, Michael R. Boyd; Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res. 48:589-601(1988) PubMed=3402281; DOI=10.1002/cyto.990090413 Douglas D. Ross, Jose V. Ordonez, Christopher C. Joneckis, Joseph R. Testa, Bruce W. Thompson; Isolation of highly multidrug-resistant P388 cells from drug-sensitive P388/S cells by flow cytometric cell sorting. Cytometry 9:359-367(1988) PubMed=1849151; DOI=10.1172/JCI115154; PMCID=PMC295200 Sudhir Gupta, Jungmee Kim, Sastry Gollapudi; Reversal of daunorubicin resistance in P388/ADR cells by itraconazole. J. Clin. Invest. 87:1467-1469(1991)
Cell line collections (Providers)	NCI-DTP; P388/ADR
Chemistry resources	ChEMBL-Cells; CHEMBL3307566 ChEMBL-Targets; CHEMBL614218 PubChem_Cell_line; CVCL_IZ75
Encyclopedic resources	Wikidata; Q54937256
Entry history
Entry creation	15-May-2017
Last entry update	14-Aug-2025
Version number	10