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Cellosaurus NB4R (CVCL_IY15)

[Text version]
Cell line name NB4R
Accession CVCL_IY15
Resource Identification Initiative To cite this cell line use: NB4R (RRID:CVCL_IY15)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_15367; All-trans-retinoic acid (ATRA; Tretinoin).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; HGNC:9113; PML + HGNC; HGNC:9864; RARA; Name(s)=PML-RARA (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Acute promyelocytic leukemia with PML-RARA (NCIt: C3182)
Acute promyelocytic leukemia (ORDO: Orphanet_520)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0005 (NB4)
Sex of cell Female
Age at sampling 23Y
Category Cancer cell line
Publications

Patent=US5589345
Michel Lanotte, Roland Berger;
Cultures of permanent lines of human promyelocytic cells and their uses for the screening of molecules utilizable in particular in the treatment of leukemias.
Patent number US5589345, 31-Dec-1996

Cross-references
Cell line databases/resources cancercelllines; CVCL_IY15
Encyclopedic resources Wikidata; Q54907540
Entry history
Entry creation15-May-2017
Last entry update19-Dec-2024
Version number15