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Cellosaurus C2ABR (CVCL_IW75)

[Text version]
Cell line name C2ABR
Synonyms Control 2 Australia BRisbane
Accession CVCL_IW75
Resource Identification Initiative To cite this cell line use: C2ABR (RRID:CVCL_IW75)
Comments From: Queensland Institute of Medical Research; Brisbane; Australia.
Population: Caucasian.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 69Y
Category Transformed cell line
Publications

PubMed=7433105; DOI=10.1093/nar/8.16.3709; PMCID=PMC324185
Jane Houldsworth, Martin Francis Lavin;
Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells.
Nucleic Acids Res. 8:3709-3720(1980)

PubMed=6504056; DOI=10.1016/0027-5107(84)90149-0
Philip Chen, F. Paula Imray, Cheviot Kidson;
Gene dosage and complementation analysis of ataxia telangiectasia lymphoblastoid cell lines assayed by induced chromosome aberrations.
Mutat. Res. 129:165-172(1984)

PubMed=2836804; DOI=10.1093/nar/16.9.3919; PMCID=PMC336565
Surinder Pal Singh, Rahmah Mohamed, C. Salmond, Martin Francis Lavin;
Reduced DNA topoisomerase II activity in ataxia-telangiectasia cells.
Nucleic Acids Res. 16:3919-3929(1988)

PubMed=1944384; DOI=10.1016/0921-8734(91)90029-B
Philip Chen, Cheviot Kidson, Martin Francis Lavin;
Heterogeneity in Alzheimer's disease: evidence from cellular radiosensitivity and complementation of this phenotype.
Mutat. Res. 256:21-27(1991)

PubMed=9150358; DOI=10.1038/sj.onc.1201037
Dianne Watters, Kum Kum Khanna, Heather J. Beamish, Geoffrey W. Birrell, Kevin Spring, Padmini Kedar, Magtouf Gatei, Deborah Stenzel, Karen Hobson, Sergei V. Kozlov, Ning Zhang ...Show all 15 authors... , Aine Farrell, Jonathan Ramsay, Richard A. Gatti, Martin Francis Lavin; Show fewer authors
Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms.
Oncogene 14:1911-1921(1997)

PubMed=11080496; DOI=10.1074/jbc.M006190200
Nuri Gueven, Katherine E. Keating, Philip Chen, Toshiyuki Fukao, Kum Kum Khanna, Dianne Watters, Peter H. Rodemann, Martin Francis Lavin;
Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia.
J. Biol. Chem. 276:8884-8891(2001)

PubMed=17347666; DOI=10.1038/sj.cdd.4402116
Nuri Gueven, Olivier J. Becherel, Orla Howe, Pin-Jhen Chen, Jean-Francois Haince, Marie-Eve Ouellet, Guy G. Poirier, Nigel Waterhouse, Markus Fusser, Bernd Epe, Josiane Menissier-de Murcia ...Show all 17 authors... , Gilbert de Murcia, Clare H. McGowan, Robert G. Parton, Carmel Mothersill, Padraic J. Grattan-Smith, Martin Francis Lavin; Show fewer authors
A novel form of ataxia oculomotor apraxia characterized by oxidative stress and apoptosis resistance.
Cell Death Differ. 14:1149-1161(2007)

PubMed=17562789; DOI=10.1083/jcb.200701042; PMCID=PMC2064358
Amila Suraweera, Olivier J. Becherel, Philip Chen, Natalie Rundle, Robert Woods, Jun Nakamura, Magtouf Gatei, Chiara Criscuolo, Alessandro Filla, Luciana Chessa, Markus Fusser ...Show all 14 authors... , Bernd Epe, Nuri Gueven, Martin Francis Lavin; Show fewer authors
Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage.
J. Cell Biol. 177:969-979(2007)

PubMed=19643912; DOI=10.1093/hmg/ddp359
Janelle Louise Harris, Burkhard Jakob, Gisela Taucher-Scholz, Grigory L. Dianov, Olivier J. Becherel, Martin Francis Lavin;
Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage.
Hum. Mol. Genet. 18:4102-4117(2009)

PubMed=25868131; DOI=10.1016/j.mrgentox.2015.03.012
Junya Kobayashi, Yuichiro Saito, Michiyo Okui, Noriko Miwa, Kenshi Komatsu;
Increased oxidative stress in AOA3 cells disturbs ATM-dependent DNA damage responses.
Mutat. Res. Genet. Toxicol. Environ. Mutagen. 782:42-50(2015)

Cross-references
Encyclopedic resources Wikidata; Q54808116
Entry history
Entry creation03-Mar-2017
Last entry update10-Sep-2024
Version number9