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Cellosaurus OCUM-8/SN38 (CVCL_IV66)

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Cell line name OCUM-8/SN38
Accession CVCL_IV66
Resource Identification Initiative To cite this cell line use: OCUM-8/SN38 (RRID:CVCL_IV66)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI_8988; SN-38 (7-ethyl-10-hydroxy-camptothecin).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Gene fusion; HGNC; HGNC:1681; CD44 + HGNC; HGNC:5465; IGF1R; Name(s)=CD44-IGFR1; Note=In frame. CD44 exon 1 fused to IGF1R exon 12 (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu271Lys (c.811G>A); ClinVar=VCV000406566; Zygosity=Homozygous (from parent cell line).
Disease Gastric diffuse adenocarcinoma (NCIt: C9159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_8389 (OCUM-8)
Sex of cell Female
Age at sampling 67Y
Category Cancer cell line
Publications

PubMed=21997136; DOI=10.1038/bjc.2011.397; PMCID=PMC3242520
Masakazu Yashiro, Hong Qiu, Tsuyoshi Hasegawa, Xiao-Tian Zhang, Taro Matsuzaki, Kosei Hirakawa;
An EGFR inhibitor enhances the efficacy of SN38, an active metabolite of irinotecan, in SN38-refractory gastric carcinoma cells.
Br. J. Cancer 105:1522-1532(2011)

Cross-references
Encyclopedic resources Wikidata; Q54931841
Entry history
Entry creation03-Mar-2017
Last entry update19-Dec-2024
Version number8