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Cellosaurus MCF-7 RR2 (CVCL_IU97)

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Cell line name MCF-7 RR2
Synonyms MCF-7_RR2
Accession CVCL_IU97
Resource Identification Initiative To cite this cell line use: MCF-7 RR2 (RRID:CVCL_IU97)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_9168; Sirolimus (Rapamycin).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3942; MTOR; Simple; p.Phe2108Leu; Zygosity=Unspecified; Note=Acquired during resistance selection process (PubMed=27279227).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=27279227; DOI=10.1038/nature17963; PMCID=PMC4902179
Vanessa Sofi Rodrik-Outmezguine, Masanori Okaniwa, Zhan Yao, Christopher J. Novotny, Claire McWhirter, Arpitha Banaji, Helen Won, Wai Wong, Mike Berger, Elisa de Stanchina, Derek G. Barratt ...Show all 15 authors... , Sabina Cosulich, Teresa Klinowska, Neal Rosen, Kevan Michael Shokat; Show fewer authors
Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor.
Nature 534:272-276(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_IU97
Encyclopedic resources Wikidata; Q54904324
Polymorphism and mutation databases Cosmic; 2553505
Entry history
Entry creation03-Mar-2017
Last entry update10-Apr-2025
Version number15