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Cellosaurus Z-119 (CVCL_IU88)

[Text version]
Cell line name Z-119
Synonyms Z119
Accession CVCL_IU88
Resource Identification Initiative To cite this cell line use: Z-119 (RRID:CVCL_IU88)
Comments Population: Latino.
Doubling time: 20-30 hours (PubMed=8600166); ~24-36 hours (ATCC=CRL-3394).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 1 fused to ABL1 exon 2 (e1a2 transcript) (PubMed=8600166; PubMed=10071072; PubMed=10576511).
Disease Adult B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2) BCR-ABL1 (NCIt: C114819)
B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) (ORDO: Orphanet_585909)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 25Y
Category Cancer cell line
Publications

PubMed=8600166; DOI=10.1002/(SICI)1097-4652(199603)166:3<618::AID-JCP17>3.0.CO;2-2
Estrov Z., Talpaz M., Zipf T.F., Kantarjian H.M., Ku S., Ouspenskaia M.V., Hirsch-Ginsberg C.F., Huh Y.O., Yee G., Kurzrock R.
Role of granulocyte-macrophage colony-stimulating factor in Philadelphia (Ph1)-positive acute lymphoblastic leukemia: studies on two newly established Ph1-positive acute lymphoblastic leukemia cell lines (Z-119 and Z-181).
J. Cell. Physiol. 166:618-630(1996)

PubMed=9067587; DOI=10.1038/sj.leu.2400571
Uphoff C.C., MacLeod R.A.F., Denkmann S.A., Golub T.R., Borkhardt A., Janssen J.W.G., Drexler H.G.
Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.
Leukemia 11:441-447(1997)

PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4
Drexler H.G., MacLeod R.A.F., Uphoff C.C.
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.
Leuk. Res. 23:207-215(1999)

PubMed=10576511; DOI=10.1016/s0145-2126(99)00131-9
Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.
ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.
Leuk. Res. 23:1055-1060(1999)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

Cross-references
Cell line collections (Providers) ATCC; CRL-3394
Encyclopedic resources Wikidata; Q54995847
Polymorphism and mutation databases Cosmic; 2491094
Entry history
Entry creation03-Mar-2017
Last entry update02-May-2024
Version number14