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Cellosaurus Pre-Alp (CVCL_IU85)

[Text version]
Cell line name Pre-Alp
Synonyms PRE-ALP; PreALP
Accession CVCL_IU85
Resource Identification Initiative To cite this cell line use: Pre-Alp (RRID:CVCL_IU85)
Comments Doubling time: ~24 hours (PubMed=8464241).
Omics: Phenotyping; Drug screening.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
B acute lymphoblastic leukemia with t(1;19)(q23;p13.3) E2A-PBX1 (TCF3-PBX1) (NCIt: C80347)
B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3) (ORDO: Orphanet_585956)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 6Y
Category Cancer cell line
Publications

PubMed=8464241
Dominique Pandrau-Garcia, Veronique Frances, Hector Martinez-Valdez, Marie-Pierre Pages, Anne-Marie Manel, Noel Philippe, Jacques Banchereau, Sem Saeland;
Characterization of a t(1;19) pre-B acute lymphoblastic leukemia (ALL) cell line which proliferates in response to IL-7.
Leukemia 7:635-642(1993)

PubMed=7919343; DOI=10.1182/blood.V84.7.2253.2253
Nathalie Renard, Valerie Duvert, Jacques Banchereau, Sem Saeland;
Interleukin-13 inhibits the proliferation of normal and leukemic human B-cell precursors.
Blood 84:2253-2260(1994)

PubMed=9067587; DOI=10.1038/sj.leu.2400571
Cord C. Uphoff, Roderick A.F. MacLeod, Sabine A. Denkmann, Todd Robert Golub, Arndt Borkhardt, Johannes W.G. Janssen, Hans Gunther Drexler;
Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.
Leukemia 11:441-447(1997)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=29786757; DOI=10.1007/s12185-018-2474-7
Chihiro Tomoyasu, Toshihiko Imamura, Toshihiro Tomii, Mio Yano, Daisuke Asai, Hiroaki Goto, Akira Shimada, Masashi Sanada, Shotaro Iwamoto, Junko Takita, Masayoshi Minegishi ...Show all 14 authors... , Takeshi Inukai, Kanji Sugita, Hajime Hosoi; Show fewer authors
Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes.
Int. J. Hematol. 108:312-318(2018)

PubMed=31305009; DOI=10.1002/cam4.2356; PMCID=PMC6718581
Atsushi Watanabe, Takeshi Inukai, Keiko Kagami, Masako Abe, Masatoshi Takagi, Takashi Fukushima, Hiroko Fukushima, Toru Nanmoku, Kiminori Terui, Tatsuya Ito, Tsutomu Toki ...Show all 29 authors... , Etsuro Ito, Junya Fujimura, Hiroaki Goto, Mikiya Endo, Thomas Look, Mark P. Kamps, Masayoshi Minegishi, Junko Takita, Toshiya Inaba, Hiroyuki Takahashi, Akira Ohara, Daisuke Harama, Tamao Shinohara, Shinpei Somazu, Hiroko Oshiro, Koshi Akahane, Kumiko Goi, Kanji Sugita; Show fewer authors
Resistance of t(17;19)-acute lymphoblastic leukemia cell lines to multiagents in induction therapy.
Cancer Med. 8:5274-5288(2019)

PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068
Minori Tamai, Shin Kasai, Koshi Akahane, Thao Nguyen Thu, Keiko Kagami, Chiaki Komatsu, Masako Abe, Atsushi Watanabe, Kumiko Goi, Kunio Miyake, Toshiya Inaba ...Show all 17 authors... , Junko Takita, Hiroaki Goto, Masayoshi Minegishi, Shotaro Iwamoto, Kanji Sugita, Takeshi Inukai; Show fewer authors
Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022)

Cross-references
Encyclopedic resources Wikidata; Q54948341
Polymorphism and mutation databases Cosmic; 2491073
Entry history
Entry creation03-Mar-2017
Last entry update14-Aug-2025
Version number11