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Cellosaurus (CVCL_IT55)

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Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Doubling time: 24 hours (PubMed=8099464); ~2-3 days (DSMZ=ACC-279).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=23833040; PubMed=30737244; Cosmic-CLP=906696; DepMap=ACH-000191).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=23833040; PubMed=30737244).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ile251Thr (c.752T>C); ClinVar=VCV000439320; Zygosity=Homozygous (PubMed=30737244; Cosmic-CLP=906696; DepMap=ACH-000191).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.56
Native American0.75
East Asian, North2.42
East Asian, South0
South Asian0.87
European, North57.43
European, South37.97
Disease Thyroid gland anaplastic carcinoma (NCIt: C3878)
Anaplastic thyroid carcinoma (ORDO: Orphanet_142)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=906696; DSMZ=ACC-279; PubMed=18713817; PubMed=30737244

Markers:
AmelogeninX
CSF1PO12 (DSMZ=ACC-279)
12,13 (Cosmic-CLP=906696; PubMed=30737244)
D2S133820,23
D3S135816,17
D5S81810,11
D7S82010,11
D8S117913,14,15 (PubMed=18713817; PubMed=30737244)
15 (DSMZ=ACC-279)
D13S31712
D16S5399,11
D18S5112,15
D19S43313,15
D21S1129,32.2
FGA18,24
Penta D9
Penta E10,17
TH019,9.3
TPOX8
vWA18,19 (PubMed=18713817)
19 (Cosmic-CLP=906696; DSMZ=ACC-279; PubMed=30737244)

Run an STR similarity search on this cell line
Publications







Virchows Arch. B. Cell. Pathol. Incl. Mol. Pathol. 57:167-174(1989)


Jerome Marshall Hershman;
Antitumor actions of cytokines on new human papillary thyroid carcinoma cell lines.
J. Clin. Endocrinol. Metab. 81:2607-2612(1996)


Martin K. Selig, Stacey R. Johnson, Anne Klibanski;
A human pituitary tumor-derived folliculostellate cell line.
J. Clin. Endocrinol. Metab. 85:1180-1187(2000)


Paula D. Bos, Xiang H.-F. Zhang, Cristina Nadal, Wei-Ping Shu, Roger R. Gomis, Don X. Nguyen, Andy J. Minn, Marc Joan van de Vijver, William Levi Gerald, John A. Foekens, Joan Massague;
Genes that mediate breast cancer metastasis to the brain.
Nature 459:1005-1009(2009)


Louis Guillou, Philippe Terrier, Alain Aurias;
Strong smooth muscle differentiation is dependent on myocardin gene amplification in most human retroperitoneal leiomyosarcomas.
Cancer Res. 69:2269-2278(2009)


Julie Adam, Ann Hedley, Gabriela Kalna, Ian Philip Mark Tomlinson, Patrick John Pollard, David George Watson, Ralph J. DeBerardinis, Tomer Shlomi, Eytan Ruppin, Eyal Gottlieb;
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
Nature 477:225-228(2011)


Yasuhiro Takashima, Ge Guo, Remco Loos, Jennifer Nichols, Gabriella Ficz, Felix Krueger, David Oxley, Fatima Santos, James Clarke, William Mansfield, Wolf Reik ...Show all 13 authors... , Paul Bertone, Austin Gerard Smith; Show fewer authors
Resetting transcription factor control circuitry toward ground-state pluripotency in human.
Cell 158:1254-1269(2014)



literature.
Cancer Res. 77:2784-2788(2017)


Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita ...Show all 16 authors... , Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar, Jun Takahashi; Show fewer authors
Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model.
Nature 548:592-596(2017)




Cancer Cell 33:386-400.e5(2018)

Cross-references
Chemistry resources PubChem_Cell_line; CVCL_1085
Encyclopedic resources Wikidata; Q54796508
Polymorphism and mutation databases Progenetix; CVCL_1085
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number44