• Mutation; HGNC; HGNC:4764; H3-3A; Simple; p.Lys28Met (c.83A>T) (H3.3K27M); ClinVar=VCV000376435; Zygosity=Unspecified (PubMed=25939062; PubMed=26115193).
  

PubMed=25939062; DOI=10.1038/nm.3855; PMCID=PMC4862411
Catherine S. Grasso, Yu-Jie Tang, Nathalene Truffaux, Noah E. Berlow, Li-Ning Liu, Marie-Anne Debily, Michael J. Quist, Lara E. Davis, Elaine C. Huang, Pamelyn J. Woo, Anitha Ponnuswami ...Show all 40 authors... , Spenser Chen, Tessa B. Johung, Wen-Chao Sun, Mari Kogiso, Yu-Chen Du, Lin Qi, Yu-Lun Huang, Marianne Hutt-Cabezas, Katherine E. Warren, Ludivine Le Dret, Paul S. Meltzer, Hua Mao, Martha Quezado, Dannis G. van Vuurden, Jinu Abraham, Maryam Fouladi, Matthew N. Svalina, Nicholas Wang, Cynthia Hawkins, Javad Nazarian, Marta M. Alonso, Eric Hutton Raabe, Esther Hulleman, Paul T. Spellman, Xiao-Nan Li, Charles Keller, Ranadip Pal, Jacques Grill, Michelle Monje; Show fewer authors
Functionally defined therapeutic targets in diffuse intrinsic pontine glioma.
Nat. Med. 21:555-559(2015)

PubMed=26115193; DOI=10.1097/NEN.0000000000000216; PMCID=PMC4596247
Isabella C. Taylor, Marianne Hutt-Cabezas, William D. Brandt, Madhuri Kambhampati, Javad Nazarian, Howard T. Chang, Katherine E. Warren, Charles George Eberhart, Eric Hutton Raabe;
Disrupting NOTCH slows diffuse intrinsic pontine glioma growth, enhances radiation sensitivity, and shows combinatorial efficacy with bromodomain inhibition.
J. Neuropathol. Exp. Neurol. 74:778-790(2015)

PubMed=28947132; DOI=10.1016/j.yexcr.2017.09.032
Michael Hananja Meel, A. Charlotte P. Sewing, Piotr Waranecki, Dennis S. Metselaar, Laurine E. Wedekind, Jan Koster, Dannis G. van Vuurden, Gertjan J.L. Kaspers, Esther Hulleman;
Culture methods of diffuse intrinsic pontine glioma cells determine response to targeted therapies.
Exp. Cell Res. 360:397-403(2017)