Cellosaurus cell line U-CH6 (CVCL

Cellosaurus U-CH6 (CVCL_IR26)

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Cell line name

U-CH6

Synonyms

UCH6

Accession

CVCL_IR26

Resource Identification Initiative

To cite this cell line use: U-CH6 (RRID:CVCL_IR26)

Comments

Doubling time: 14 days (PubMed=26183925).
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Skin; UBERON=UBERON_0002097.

Sequence variations

Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro72Arg (c.215C>G); ClinVar=VCV000012351; Zygosity=Unspecified (PubMed=28515451).

Disease

Sacral chordoma (NCIt: C129927)
Chordoma (ORDO: Orphanet_178)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

56Y

Category

Cancer cell line

STR profile

Source(s): PubMed=26183925

Markers:

Amelogenin	X,Y
CSF1PO	10,11
D1S1656	17
D2S441	11
D2S1338	18,20
D3S1358	17
D5S818	12
D7S820	10
D8S1179	12
D10S1248	17
D12S391	18
D13S317	8
D16S539	12
D18S51	15
D19S433	13,16.2
D21S11	29
D22S1045	15
FGA	19,21
Penta D	12
Penta E	13,20
TH01	8
TPOX	8,11
vWA	16

Web pages

Info; Chordoma Foundation; -; https://www.chordomafoundation.org/researchers/disease-models/u-ch6/

Publications

PubMed=26183925; DOI=10.1158/0008-5472.CAN-14-3270
Adrian von Witzleben, Lukas T. Goerttler, Ralf Marienfeld, Holger Barth, Andre Lechel, Kevin Mellert, Michael J. Bohm, Marko Kornmann, Regine Mayer-Steinacker, Alexandra von Baer, Markus Schultheiss ...Show all 15 authors... , Adrienne Margaret Flanagan, Peter Moller, Silke Bruderlein, Thomas F.E. Barth; Show fewer authors
Preclinical characterization of novel chordoma cell systems and their targeting by pharmocological inhibitors of the CDK4/6 cell-cycle pathway.
Cancer Res. 75:3823-3831(2015)

PubMed=28515451; DOI=10.1038/s41598-017-02174-5; PMCID=PMC5435709
Daniela Jager, Thomas F.E. Barth, Silke Bruderlein, Angelika Scheuerle, Beate Rinner, Adrian von Witzleben, Andre Lechel, Patrick Meyer, Regine Mayer-Steinacker, Alexandra von Baer, Markus Schultheiss ...Show all 14 authors... , Christian R. Wirtz, Peter Moller, Kevin Mellert; Show fewer authors
HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas.
Sci. Rep. 7:2032.1-2032.12(2017)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_IR26

Encyclopedic resources

Wikidata; Q54973619

Gene expression databases

GEO; GSM1673851
GEO; GSM1673852

Entry history

Entry creation

03-Mar-2017

Last entry update

10-Apr-2025

Version number