Cellosaurus cell line U-CH3 (CVCL

Cellosaurus U-CH3 (CVCL_IR25)

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Cell line name

U-CH3

Synonyms

UCH3

Accession

CVCL_IR25

Resource Identification Initiative

To cite this cell line use: U-CH3 (RRID:CVCL_IR25)

Comments

Senescence: Seems not to grow above ~17 PDL and is therefore not going to be distributed (personal communication of Cogswell, Patty).
Doubling time: 8 days (PubMed=26183925).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Bone, sacrum; UBERON=UBERON_0003690.

Sequence variations

Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro72Arg (c.215C>G); ClinVar=VCV000012351; Zygosity=Unspecified (PubMed=28515451).

Disease

Sacral chordoma (NCIt: C129927)
Chordoma (ORDO: Orphanet_178)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

65Y

Category

Cancer cell line

STR profile

Source(s): PubMed=26183925

Markers:

Amelogenin	X
CSF1PO	10,13
D1S1656	15,17
D2S441	10,11
D2S1338	18,22
D3S1358	16
D5S818	12
D7S820	11,12
D8S1179	16
D10S1248	15
D12S391	17,18
D13S317	11
D16S539	12,13
D18S51	17
D19S433	13,14
D21S11	30
D22S1045	11
FGA	26
Penta D	10
Penta E	7,14
TH01	9
TPOX	8,9
vWA	17,18

Publications

PubMed=26183925; DOI=10.1158/0008-5472.CAN-14-3270
Adrian von Witzleben, Lukas T. Goerttler, Ralf Marienfeld, Holger Barth, Andre Lechel, Kevin Mellert, Michael J. Bohm, Marko Kornmann, Regine Mayer-Steinacker, Alexandra von Baer, Markus Schultheiss ...Show all 15 authors... , Adrienne Margaret Flanagan, Peter Moller, Silke Bruderlein, Thomas F.E. Barth; Show fewer authors
Preclinical characterization of novel chordoma cell systems and their targeting by pharmocological inhibitors of the CDK4/6 cell-cycle pathway.
Cancer Res. 75:3823-3831(2015)

PubMed=28515451; DOI=10.1038/s41598-017-02174-5; PMCID=PMC5435709
Daniela Jager, Thomas F.E. Barth, Silke Bruderlein, Angelika Scheuerle, Beate Rinner, Adrian von Witzleben, Andre Lechel, Patrick Meyer, Regine Mayer-Steinacker, Alexandra von Baer, Markus Schultheiss ...Show all 14 authors... , Christian R. Wirtz, Peter Moller, Kevin Mellert; Show fewer authors
HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas.
Sci. Rep. 7:2032.1-2032.12(2017)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_IR25

Encyclopedic resources

Wikidata; Q54973618

Gene expression databases

GEO; GSM1673849
GEO; GSM1673850

Entry history

Entry creation

03-Mar-2017

Last entry update

10-Apr-2025

Version number