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Cellosaurus U-CH7 (CVCL_IR23)

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Cell line name U-CH7
Synonyms UCH7
Accession CVCL_IR23
Resource Identification Initiative To cite this cell line use: U-CH7 (RRID:CVCL_IR23)
Comments Doubling time: 7 days (PubMed=26183925); 8 days (Chordoma Foundation).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Bone, sacrum; UBERON=UBERON_0003690.
Disease Sacral chordoma (NCIt: C129927)
Chordoma (ORDO: Orphanet_178)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 67Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3404; PubMed=26183925; PubMed=27102572

Markers:
AmelogeninX,Y
CSF1PO12
D1S165617.3
D2S44110,14
D2S133823
D3S135817
D5S81812,13
D7S82010,11
D8S117914,16
D10S124813
D12S39115,19
D13S31710 (ATCC=CRL-3404; PubMed=27102572)
10,12 (PubMed=26183925)
D16S53910,12
D18S5116
D19S43313,14
D21S1130,33.2
D22S104515
FGA22,24
Penta D12,13
Penta E12,15
TH017
TPOX8,11
vWA16,17

Run an STR similarity search on this cell line
Web pages Info; Chordoma Foundation; -; https://www.chordomafoundation.org/researchers/disease-models/u-ch7/
Publications

PubMed=26183925; DOI=10.1158/0008-5472.CAN-14-3270
Adrian von Witzleben, Lukas T. Goerttler, Ralf Marienfeld, Holger Barth, Andre Lechel, Kevin Mellert, Michael Bohm, Marko Kornmann, Regine Mayer-Steinacker, Alexandra von Baer, Markus Schultheiss ...Show all 15 authors... , Adrienne M. Flanagan, Peter Moller, Silke Bruderlein, Thomas F.E. Barth; Show fewer authors
Preclinical characterization of novel chordoma cell systems and their targeting by pharmocological inhibitors of the CDK4/6 cell-cycle pathway.
Cancer Res. 75:3823-3831(2015)

PubMed=27102572; DOI=10.1002/path.4729; PMCID=PMC4922416
Susanne Scheipl, Michelle Barnard, Lucia Cottone, Mette Jorgensen, David Harold Drewry, William J. Zuercher, Fabrice Turlais, Hong-Tao Ye, Ana P. Leite, James A. Smith, Andreas Leithner ...Show all 19 authors... , Peter Moller, Silke Bruderlein, Naomi Guppy, Fernanda Amary, Roberto Tirabosco, Sandra J. Strauss, Nischalan Pillay, Adrienne M. Flanagan; Show fewer authors
EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen.
J. Pathol. 239:320-334(2016)

PubMed=28515451; DOI=10.1038/s41598-017-02174-5; PMCID=PMC5435709
Daniela Jager, Thomas F.E. Barth, Silke Bruderlein, Angelika Scheuerle, Beate Rinner, Adrian von Witzleben, Andre Lechel, Patrick Meyer, Regine Mayer-Steinacker, Alexandra von Baer, Markus Schultheiss ...Show all 14 authors... , Christian R. Wirtz, Peter Moller, Kevin Mellert; Show fewer authors
HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas.
Sci. Rep. 7:2032-2032(2017)

Cross-references
Cell line collections (Providers) ATCC; CRL-3404
Encyclopedic resources Wikidata; Q54973620
Gene expression databases GEO; GSM1673853
GEO; GSM1673854
Polymorphism and mutation databases Cosmic; 2663859
Entry history
Entry creation03-Mar-2017
Last entry update10-Apr-2025
Version number11