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Cellosaurus U-CH7 (CVCL_IR23)

[Text version]
Cell line name U-CH7
Synonyms UCH7
Accession CVCL_IR23
Resource Identification Initiative To cite this cell line use: U-CH7 (RRID:CVCL_IR23)
Comments Doubling time: 7 days (PubMed=26183925); 8 days (Chordoma Foundation).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Bone, sacrum; UBERON=UBERON_0003690.
Disease Sacral chordoma (NCIt: C129927)
Chordoma (ORDO: Orphanet_178)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 67Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3404; PubMed=26183925; PubMed=27102572

Markers:
AmelogeninX,Y
CSF1PO12
D1S165617.3
D2S44110,14
D2S133823
D3S135817
D5S81812,13
D7S82010,11
D8S117914,16
D10S124813
D12S39115,19
D13S31710 (ATCC=CRL-3404; PubMed=27102572)
10,12 (PubMed=26183925)
D16S53910,12
D18S5116
D19S43313,14
D21S1130,33.2
D22S104515
FGA22,24
Penta D12,13
Penta E12,15
TH017
TPOX8,11
vWA16,17

Run an STR similarity search on this cell line
Web pages Info; Chordoma Foundation; -; https://www.chordomafoundation.org/researchers/disease-models/u-ch7/
Publications

PubMed=26183925; DOI=10.1158/0008-5472.CAN-14-3270
von Witzleben A., Goerttler L.T., Marienfeld R., Barth H., Lechel A., Mellert K., Bohm M., Kornmann M., Mayer-Steinacker R., von Baer A., Schultheiss M., Flanagan A.M., Moller P., Bruderlein S., Barth T.F.E.
Preclinical characterization of novel chordoma cell systems and their targeting by pharmocological inhibitors of the CDK4/6 cell-cycle pathway.
Cancer Res. 75:3823-3831(2015)

PubMed=27102572; DOI=10.1002/path.4729; PMCID=PMC4922416
Scheipl S., Barnard M., Cottone L., Jorgensen M., Drewry D.H., Zuercher W.J., Turlais F., Ye H.-T., Leite A.P., Smith J.A., Leithner A., Moller P., Bruderlein S., Guppy N., Amary F., Tirabosco R., Strauss S.J., Pillay N., Flanagan A.M.
EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen.
J. Pathol. 239:320-334(2016)

PubMed=28515451; DOI=10.1038/s41598-017-02174-5; PMCID=PMC5435709
Jager D., Barth T.F.E., Bruderlein S., Scheuerle A., Rinner B., von Witzleben A., Lechel A., Meyer P., Mayer-Steinacker R., von Baer A., Schultheiss M., Wirtz C.R., Moller P., Mellert K.
HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas.
Sci. Rep. 7:2032-2032(2017)

Cross-references
Cell line collections (Providers) ATCC; CRL-3404
Encyclopedic resources Wikidata; Q54973620
Gene expression databases GEO; GSM1673853
GEO; GSM1673854
Polymorphism and mutation databases Cosmic; 2663859
Entry history
Entry creation03-Mar-2017
Last entry update10-Apr-2025
Version number11