| Cell line name |
Hs578T-Dox |
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| Synonyms |
Hs578T/Doxo |
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| Accession |
CVCL_IR02 |
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| Resource Identification Initiative |
To cite this cell line use: Hs578T-Dox (RRID:CVCL_IR02) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Breast; UBERON=UBERON_0000310. |
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| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012612; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val157Phe (c.469G>T); ClinVar=VCV000012353; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Invasive breast carcinoma of no special type (NCIt: C4194) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0332 (Hs 578T) |
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| Sex of cell |
Female |
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| Age at sampling |
74Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=7902062
Manuel de la Torre, Xiao-Yong Hao, Rolf Larsson, Peter Nygren, Takashi Tsuruo, Bengt Mannervik, Jonas Bergh;
Characterization of four doxorubicin adapted human breast cancer cell lines with respect to chemotherapeutic drug sensitivity, drug resistance associated membrane proteins and glutathione transferases.
Anticancer Res. 13:1425-1430(1993) PubMed=10571255; DOI=10.1016/S0006-2952(99)00262-2
Osten Jonsson, Parviz Behnam-Motlagh, Mattias Persson, Roger Henriksson, Kjell Grankvist;
Increase in doxorubicin cytotoxicity by carvedilol inhibition of P-glycoprotein activity.
Biochem. Pharmacol. 58:1801-1806(1999) PubMed=15239129; DOI=10.1002/ijc.20300
Chuan-Xi Cai, Jian-Wen Chen;
Overexpression of caveolin-1 induces alteration of multidrug resistance in Hs578T breast adenocarcinoma cells.
Int. J. Cancer 111:522-529(2004) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_IR02
|
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| Encyclopedic resources |
Wikidata; Q54896337
|
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| Entry history |
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| Entry creation | 03-Mar-2017 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 14 |
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