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Cellosaurus MCF-10A-erbB-2 (CVCL_IP85)

[Text version]
Cell line name MCF-10A-erbB-2
Synonyms MCF-10AerbB-2
Accession CVCL_IP85
Resource Identification Initiative To cite this cell line use: MCF-10A-erbB-2 (RRID:CVCL_IP85)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:3430; ERBB2.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0598 (MCF-10A)
Sex of cell Female
Age at sampling 36Y
Category Spontaneously immortalized cell line
Publications

PubMed=10433219; DOI=10.1210/endo.140.8.6939
Kathleen M. Woods Ignatoski, Allison J. Lapointe, Eric H. Radany, Stephen P. Ethier;
erbB-2 overexpression in human mammary epithelial cells confers growth factor independence.
Endocrinology 140:3615-3622(1999)

Cross-references
Encyclopedic resources Wikidata; Q54904294
Entry history
Entry creation03-Mar-2017
Last entry update14-Aug-2025
Version number12