Cellosaurus cell line BT245 (CVCL

Cellosaurus BT245 (CVCL_IP13)

[Text version]

Cell line name

BT245

Synonyms

BT-245; BT 245; BCH245; Boston Children's Hospital 245; CPDM_0797X

Accession

CVCL_IP13

Resource Identification Initiative

To cite this cell line use: BT245 (RRID:CVCL_IP13)

Comments

Part of: Center for Patient Derived Models (CPDM) at Dana-Farber Cancer Institute cell line panel.
Population: Caucasian.
Characteristics: Low-passage-number culture.
Characteristics: Grows as neurospheres in suspension (PubMed=34610309; Millipore=SCC219).
Derived from site: In situ; Brain; UBERON=UBERON_0000955.

Sequence variations

Mutation; HGNC; HGNC:4764; H3-3A; Simple; p.Lys28Met (c.83A>T) (H3.3K27M); ClinVar=VCV000376435; Zygosity=Unspecified (Patent=US20200384022).

Disease

Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

8Y8M

Category

Cancer cell line

STR profile

Source(s): Millipore=SCC219

Markers:

Amelogenin	X,Y
CSF1PO	12
D3S1358	18
D5S818	12
D7S820	8,10
D8S1179	11,13
D13S317	11
D16S539	11
D18S51	14
D21S11	31.2
FGA	19
Penta D	12
Penta E	14
TH01	9
TPOX	8,12
vWA	14,15

Web pages

Provider; CPDM; CPDM_0797X; https://docs.google.com/spreadsheets/d/1sxAPF3p6xK2h01zaiQ1ExCWwzhxeZ-oDLN3s3LeJq98/edit?usp=sharing

Publications

PubMed=25366336; DOI=10.1093/neuonc/nou303; PMCID=PMC4482855
Green A.L., Ramkissoon S.H., McCauley D., Jones K., Perry J.A., Hsu J.H.-R., Ramkissoon L.A., Maire C.L., Hubbell-Engler B., Knoff D.S., Shacham S., Ligon K.L., Kung A.L.-J.
Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma.
Neuro-oncol. 17:697-707(2015)

Patent=US20200384022
Suva M.L., Bernstein B.E., Regev A., Filbin M.G., Tirosh I., Hovestadt V.
Methods and compositions for targeting developmental and oncogenic programs in H3K27M gliomas.
Patent number US20200384022, 10-Dec-2020

PubMed=34610309; DOI=10.1016/j.celrep.2021.109788
Stockslager M.A., Malinowski S., Touat M., Yoon J.C., Geduldig J., Mirza M., Kim A.S., Wen P.Y.-C., Chow K.-H., Ligon K.L., Manalis S.R.
Functional drug susceptibility testing using single-cell mass predicts treatment outcome in patient-derived cancer neurosphere models.
Cell Rep. 37:109788.1-109788.12(2021)

Cross-references

Cell line collections (Providers)

Millipore; SCC219

Cell line databases/resources

cancercelllines; CVCL_IP13

Anatomy/cell type resources

BTO; BTO_0005952

Chemistry resources

PharmacoDB; BT245_130_2019

Encyclopedic resources

Wikidata; Q54798426

Entry history

Entry creation

03-Mar-2017

Last entry update

10-Apr-2025

Version number