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Cellosaurus BT145 (CVCL_IP10)

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Cell line name BT145
Synonyms BT-145; BT 145; CPDM_1279X
Accession CVCL_IP10
Resource Identification Initiative To cite this cell line use: BT145 (RRID:CVCL_IP10)
Comments Part of: Center for Patient Derived Models (CPDM) at Dana-Farber Cancer Institute cell line panel.
Population: Caucasian.
Characteristics: Low-passage-number culture.
Characteristics: Can grow as a neurosphere (PubMed=34610309).
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing; Low read coverage.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Brain, right parietal lobe; UBERON=UBERON_0002802.
Sequence variations
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 87Y
Category Cancer cell line
Web pages Provider; CPDM; CPDM_1279X; https://docs.google.com/spreadsheets/d/1sxAPF3p6xK2h01zaiQ1ExCWwzhxeZ-oDLN3s3LeJq98/edit?usp=sharing
Publications

PubMed=24440720; DOI=10.1016/j.celrep.2013.12.032; PMCID=PMC4041390
Yakov Chudnovsky, Dohoon Kim, Si-Yuan Zheng, Warren A. Whyte, Mukesh Bansal, Mark-Anthony Bray, Shuba Gopal, Matthew A. Theisen, Steve Bilodeau, Prathapan Thiru, Julien Muffat ...Show all 29 authors... , Omer Hidir Yilmaz, Maya Mitalipova, Kevin Douglas Woolard, Jeongwu Lee, Riko Nishimura, Nobuo Sakata, Howard Alan Fine, Anne Elizabeth Carpenter, Serena J. Silver, Roel G.W. Verhaak, Andrea Califano, Richard Allen Young, Keith Lloyd Ligon, Ingo K. Mellinghoff, David E. Root, David M. Sabatini, William Chun Hahn, Milan G. Chheda; Show fewer authors
ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state.
Cell Rep. 6:313-324(2014)

PubMed=25184684; DOI=10.1371/journal.pone.0106694; PMCID=PMC4153667
Karl Holmberg Olausson, Cecile L. Maire, Samer Haidar, Jason Ling, Emily Learner, Monica Nister, Keith Lloyd Ligon;
Prominin-1 (CD133) defines both stem and non-stem cell populations in CNS development and gliomas.
PLoS ONE 9:e106694.1-e106694.11(2014)

PubMed=25366336; DOI=10.1093/neuonc/nou303; PMCID=PMC4482855
Adam L. Green, Shakti H. Ramkissoon, Dilara McCauley, Kristen Jones, Jennifer A. Perry, Jessie Hao-Ru Hsu, Lori A. Ramkissoon, Cecile L. Maire, Benjamin Hubbell-Engler, David S. Knoff, Sharon Shacham ...Show all 13 authors... , Keith Lloyd Ligon, Andrew Li-Jen Kung; Show fewer authors
Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma.
Neuro-oncol. 17:697-707(2015)

PubMed=27723727; DOI=10.1038/nbt.3697; PMCID=PMC5142231
Mark M. Stevens, Cecile L. Maire, Nigel Chou, Mark A. Murakami, David S. Knoff, Yuki Kikuchi, Robert J. Kimmerling, Hui-Yun Liu, Samer Haidar, Nicholas L. Calistri, Nathan Cermak ...Show all 18 authors... , Selim Olcum, Nicolas A. Cordero, Ahmed Idbaih, Patrick Yung-Chih Wen, David M. Weinstock, Keith Lloyd Ligon, Scott R. Manalis; Show fewer authors
Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate.
Nat. Biotechnol. 34:1161-1167(2016)

PubMed=34610309; DOI=10.1016/j.celrep.2021.109788
Max A. Stockslager, Seth Malinowski, Mehdi Touat, Jennifer C. Yoon, Jack Geduldig, Mahnoor Mirza, Annette Sunhi Kim, Patrick Yung-Chih Wen, Kin-Hoe Chow, Keith Lloyd Ligon, Scott R. Manalis;
Functional drug susceptibility testing using single-cell mass predicts treatment outcome in patient-derived cancer neurosphere models.
Cell Rep. 37:109788.1-109788.12(2021)

Cross-references
Anatomy/cell type resources BTO; BTO_0005950
Chemistry resources PharmacoDB; BT145_116_2019
Encyclopedic resources Wikidata; Q54798421
Entry history
Entry creation03-Mar-2017
Last entry update10-Apr-2025
Version number10