Cellosaurus cell line CuFi-2 (CVCL

Cellosaurus CuFi-2 (CVCL_IN82)

Cross-references
Cell line name	CuFi-2
Synonyms	Cystic Fibrosis, University of Iowa-2
Accession	CVCL_IN82
Resource Identification Initiative	To cite this cell line use: CuFi-2 (RRID:CVCL_IN82)
Comments	Karyotypic information: 47,XY,+20 [6]; 48,XY,+5,+20 [2]; 48,XY,i(7)(p10),+20 [2] (PubMed=12676769). Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT. Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6. Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7. Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo. Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16). Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031. Cell type: Epithelial cell of bronchus; CL=CL_0002328.
Sequence variations	Mutation; HGNC; HGNC:1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Homozygous (PubMed=12676769).
Disease	Cystic fibrosis (NCIt: C2975) Cystic fibrosis (ORDO: Orphanet_586)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	Age unspecified
Category	Transformed cell line
Publications	PubMed=12676769; DOI=10.1152/ajplung.00355.2002 Joseph Zabner, Phil Karp, Michael Seiler, Stacia L. Phillips, Calista J. Mitchell, Mimi T. Saavedra, Michael Welsh, Aloysius J. Klingelhutz; Development of cystic fibrosis and noncystic fibrosis airway cell lines. Am. J. Physiol. Lung Cell. Mol. Physiol. 284:L844-L854(2003)
Encyclopedic resources	Wikidata; Q54814855
Entry history
Entry creation	01-Dec-2016
Last entry update	14-Aug-2025
Version number	17