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Cellosaurus mSEC1-CF (CVCL_IN76)

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Cell line name mSEC1-CF
Accession CVCL_IN76
Resource Identification Initiative To cite this cell line use: mSEC1-CF (RRID:CVCL_IN76)
Comments Knockout cell: Method=KO mouse; MGI; MGI:88388; Cftr.
Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58).
Derived from site: In situ; Salivary gland, submandibular gland; UBERON=UBERON_0001736.
Cell type: Epithelial cell; CL=CL_0000066.
Sequence variations
  • Mutation; MGI; MGI:88388; Cftr; Simple; p.Ser489Ter (c.1466C>A); Zygosity=Homozygous (PubMed=11121394).
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: [(CBA/Ca x C57BL/10)Tg(H2Kb-tsA58) Immortomouse x (C57BL/6J x 129)Cftr-/-].
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Conditionally immortalized cell line
Publications

PubMed=11121394; DOI=10.1152/ajpcell.2001.280.1.C228
Marcia Takacs-Jarrett, William E. Sweeney, Ellis D. Avner, Calvin U. Cotton;
Generation and phenotype of cell lines derived from CF and non-CF mice that carry the H-2K(b)-tsA58 transgene.
Am. J. Physiol. Cell Physiol. 280:C228-C236(2001)

PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040
Dieter C. Gruenert, Marjolaine Willems, Jean-Jacques Cassiman, Raymond A. Frizzell;
Established cell lines used in cystic fibrosis research.
J. Cyst. Fibros. 3:191-196(2004)

Cross-references
Encyclopedic resources Wikidata; Q54906842
Entry history
Entry creation01-Dec-2016
Last entry update14-Aug-2025
Version number11