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Cellosaurus MDA-MB-231 ERbetaDBD (CVCL_IN19)

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Cell line name MDA-MB-231 ERbetaDBD
Synonyms MDA Mb231 (ERbDBD)
Accession CVCL_IN19
Resource Identification Initiative To cite this cell line use: MDA-MB-231 ERbetaDBD (RRID:CVCL_IN19)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:3468; ESR2 (Note=ERE-binding defective).
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=19321454; DOI=10.1074/jbc.M900365200; PMCID=PMC2685708
Stephanie L. Nott, Yan-Fang Huang, Xiao-Dong Li, Brian R. Fluharty, Xing Qiu, Wade V. Welshons, Shu-Yuan Yeh, Mesut Muyan;
Genomic responses from the estrogen-responsive element-dependent signaling pathway mediated by estrogen receptor alpha are required to elicit cellular alterations.
J. Biol. Chem. 284:15277-15288(2009)

Cross-references
Cell line databases/resources cancercelllines; CVCL_IN19
Encyclopedic resources Wikidata; Q54904586
Gene expression databases GEO; GSM246303
GEO; GSM246304
GEO; GSM246305
GEO; GSM246306
GEO; GSM246307
GEO; GSM246308
Entry history
Entry creation01-Dec-2016
Last entry update10-Apr-2025
Version number19