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Cellosaurus M229R5-PLX (CVCL_IM73)

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Cell line name M229R5-PLX
Accession CVCL_IM73
Resource Identification Initiative To cite this cell line use: M229R5-PLX (RRID:CVCL_IM73)
Comments Selected for resistance to: ChEBI; CHEBI_63637; Vemurafenib (Zelboraf; PLX4032).
Sequence variations
  • Gene deletion; HGNC; HGNC:9588; PTEN; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_D748 (M229)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=26359985; DOI=10.1016/j.cell.2015.07.061; PMCID=PMC4821508
Willy Hugo, Hu-Bing Shi, Lu Sun, Marco Piva, Chun-Ying Song, Xiang-Ju Kong, Gatien Moriceau, Aayoung Hong, Kimberly Brown Dahlman, Douglas B. Johnson, Jeffrey Alan Sosman ...Show all 13 authors... , Antoni Ribas, Roger S. Lo; Show fewer authors
Non-genomic and immune evolution of melanoma acquiring MAPKi resistance.
Cell 162:1271-1285(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_IM73
Encyclopedic resources Wikidata; Q54903543
Gene expression databases GEO; GSM1588915
Entry history
Entry creation01-Dec-2016
Last entry update19-Dec-2024
Version number11