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Cellosaurus OVCAR-8 RIIB (CVCL_IM66)

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Cell line name OVCAR-8 RIIB
Accession CVCL_IM66
Resource Identification Initiative To cite this cell line use: OVCAR-8 RIIB (RRID:CVCL_IM66)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:9392; PRKAR2B.
Omics: Transcriptomics; Microarray.
Sequence variations
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gln26Arg (c.77A>G); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3430; ERBB2; Simple; p.Gly776Val (c.2327G>T); ClinVar=VCV000163410; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Pro121His (c.362C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.376-1G>A (p.Tyr126_Lys132del, c.376_396del21); ClinVar=VCV000481003; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1629 (OVCAR-8)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
Publications

PubMed=18822129; DOI=10.1186/1755-8794-1-43; PMCID=PMC2577111
Christopher Cheadle, Maria Nesterova, Tonya Watkins, Kathleen Carole Barnes, John C. Hall, Antony Rosen, Kevin G. Becker, Yoon S. Cho-Chung;
Regulatory subunits of PKA define an axis of cellular proliferation/differentiation in ovarian cancer cells.
BMC Med. Genomics 1:43.1-43.14(2008)

Cross-references
Cell line databases/resources cancercelllines; CVCL_IM66
Encyclopedic resources Wikidata; Q54937017
Gene expression databases GEO; GSM322540
GEO; GSM322541
GEO; GSM322542
Entry history
Entry creation01-Dec-2016
Last entry update10-Apr-2025
Version number15