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Cellosaurus K562 HHT (CVCL_IM25)

[Text version]
Cell line name K562 HHT
Synonyms K562-HHT; K562HHT
Accession CVCL_IM25
Resource Identification Initiative To cite this cell line use: K562 HHT (RRID:CVCL_IM25)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_71019; Omacetaxine mepesuccinate (Homoharringtonine; HHT).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=7987716
Jun-Ling Han, Wen-Wei Yan, Qi-Jun Qian, Hong Shi, Ming-Zhe Han, Lu-Gui Qiu, Si-Zhou Feng;
Two homoharringtonine resistant leukemic cell lines (K562 HHT and L1210 HHT): establishment, characterization and mechanisms of action.
Zhonghua Yi Xue Za Zhi 74:424-427(1994)

Cross-references
Encyclopedic resources Wikidata; Q54899376
Entry history
Entry creation01-Dec-2016
Last entry update19-Dec-2024
Version number17