| Cell line name |
OCUM-8/OXA |
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| Accession |
CVCL_IL00 |
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| Resource Identification Initiative |
To cite this cell line use: OCUM-8/OXA (RRID:CVCL_IL00) |
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| Comments |
Population: Japanese.
Selected for resistance to: ChEBI; CHEBI_31941; Oxaliplatin (Elotaxin; L-OHP).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795. |
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| Sequence variations |
- Gene fusion; HGNC; HGNC:1681; CD44 + HGNC; HGNC:5465; IGF1R; Name(s)=CD44-IGFR1; Note=In frame. CD44 exon 1 fused to IGF1R exon 12 (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu271Lys (c.811G>A); ClinVar=VCV000406566; Zygosity=Homozygous (from parent cell line).
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| Disease |
Gastric diffuse adenocarcinoma (NCIt: C9159) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_8389 (OCUM-8) |
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| Sex of cell |
Female |
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| Age at sampling |
67Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=21997136; DOI=10.1038/bjc.2011.397; PMCID=PMC3242520
Masakazu Yashiro, Hong Qiu, Tsuyoshi Hasegawa, Xiao-Tian Zhang, Taro Matsuzaki, Kosei Hirakawa;
An EGFR inhibitor enhances the efficacy of SN38, an active metabolite of irinotecan, in SN38-refractory gastric carcinoma cells.
Br. J. Cancer 105:1522-1532(2011) PubMed=27157913; DOI=10.1016/j.canlet.2016.05.002
Katsuyuki Takahashi, Masako Tanaka, Masakazu Yashiro, Masaki Matsumoto, Asuka Ohtsuka, Keiichi I. Nakayama, Yasukatsu Izumi, Katsuya Nagayama, Katsuyuki Miura, Hiroshi Iwao, Masayuki Shiota;
Protection of stromal cell-derived factor 2 by heat shock protein 72 prevents oxaliplatin-induced cell death in oxaliplatin-resistant human gastric cancer cells.
Cancer Lett. 378:8-15(2016) |
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| Cross-references |
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| Encyclopedic resources |
Wikidata; Q54931839
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| Entry history |
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| Entry creation | 03-Mar-2017 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 8 |
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