Cellosaurus cell line MD-IGF-I (CVCL

Cellosaurus MD-IGF-I (CVCL_HG41)

Cross-references
Cell line name	MD-IGF-I
Accession	CVCL_HG41
Resource Identification Initiative	To cite this cell line use: MD-IGF-I (RRID:CVCL_HG41)
Comments	Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR). Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo. Genetic integration: Method=Transfection; Gene=UniProtKB; P10763; Sheep IGF1. Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen. Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58). Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911. Cell type: Mammary alveolar epithelial cell; CL=CL_0002325.
Species of origin	Bos taurus (Bovine) (NCBI Taxonomy: 9913) Breed/subspecies: Holstein; VBO=VBO_0000237.
Hierarchy	Parent: CVCL_U226 (MAC-T)
Sex of cell	Female
Age at sampling	Adult
Category	Transformed cell line
Publications	PubMed=1480169; DOI=10.1210/mend.6.11.1480169 Donato Romagnolo, Robert Michael Akers, Eric A. Wong, Pat L. Boyle, Thomas B. McFadden, Jeffrey D. Turner; Overexpression of ovine insulin-like growth factor-I stimulates autonomous autocrine or paracrine growth in bovine mammary-derived epithelial cells. Mol. Endocrinol. 6:1774-1780(1992) Patent=US5455164 Jeffrey D. Turner; Ruminant immortalized mammary epithelial cell lines. Patent number US5455164, 03-Oct-1995
Encyclopedic resources	Wikidata; Q54904543
Entry history
Entry creation	01-Dec-2016
Last entry update	14-Aug-2025
Version number	12